Literature summary for 3.1.1.79 extracted from

Manna, P.R.; Cohen-Tannoudji, J.; Counis, R.; Garner, C.W.; Huhtaniemi, I.; Kraemer, F.B.; Stocco, D.M.
Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein (2013), J. Biol. Chem., 288, 8505-8518.

Search for more literature for 3.1.1.79

Protein Variants

Protein Variants	Comment	Organism
additional information	cells overexpressing the enzyme increase the efficacy of liver X receptor ligands on steroidogenic acute regulatory protein expression and steroid synthesis, suggesting enzyme-mediated steroidogenesis entails enhanced oxysterol production	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
CAY10499	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	a Leydig tumor strain	-
Mus musculus MA-10	-	a Leydig tumor strain	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	reversible phosphorylation, the enzyme is phosphorylated at Ser660, Ser563, and Ser565, activation of the protein kinase A pathway, by a cAMP analogue dibutyryl cyclic AMP, enhances expression of the enzyme and its phosphorylationat Ser660 and Ser563, but not at Ser565	Mus musculus

Source Tissue

Source Tissue	Comment	Organism	Textmining
Leydig cell	-	Mus musculus	-
MA-10 cell	MA-10 mouse Leydig tumor cells	Mus musculus	-
testis	-	Mus musculus	-

Subunits

Subunits	Comment	Organism
?	x * 81000-83000, phosphorylated enzyme, SDS-PAGE	Mus musculus

Synonyms

Synonyms	Comment	Organism
HSL	-	Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Mus musculus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	-	assay at	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	activation of the protein kinase A pathway, by a cAMP analogue dibutyryl cyclic AMP, enhances expression of the enzyme and its phosphorylation at Ser660 and Ser563, but not at Ser565, concomitant with increased enzyme activity. An increase in enzyme is correlated with the liver X receptor target genes, steroid receptor element-binding protein 1c, and ATP binding cassette transporter A1	up

General Information

General Information	Comment	Organism
malfunction	depletion of the enzyme affects lipoprotein-derived cellular cholesterol influx, diminishes the supply of cholesterol to the mitochondria, and results in the repression of steroidogenic acute regulatory protein and phospho-steroidogenic acute regulatory protein levels	Mus musculus
additional information	cells deficient in liver X receptors exhibit decreased enzyme responsiveness	Mus musculus
physiological function	the enzyme is primarily involved in catalyzing cholesteryl ester hydrolysis and plays an important role in the regulation of cAMP-mediated steroidogenic acute regulatory protein expression and steroidogenesis through modulation of liver X receptor pathways. The enzyme-dependent regulation of steroidogenesis predominantly involves liver X recetor signaling. Enzyme-mediated steroidogenesis entails enhanced oxysterol production. Hormonal control of the enzyme activity is primarily mediated by the phosphorylation of serine residues, Ser563, Ser659, and Ser660	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)