Literature summary for 3.1.1.79 extracted from

Wang, S.P.; Wu, J.W.; Bourdages, H.; Lefebvre, J.F.; Casavant, S.; Leavitt, B.R.; Labuda, D.; Trasler, J.; Smith, C.E.; Hermo, L.; Mitchell, G.A.
The catalytic function of hormone-sensitive lipase is essential for fertility in male mice (2014), Endocrinology, 155, 3047-3053.

Search for more literature for 3.1.1.79

Cloned(Commentary)

Cloned (Comment)	Organism
gene Lipe, encodes a specific HSL isoform including a 313 amino acid N-terminus encoded by the testis-specific exon T1	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of mice that express mutant enzyme transgenes only in postmeiotic germ cells on an enzyme-deficient background: one transgene expressed's human enzyme lacking enzyme activity but containing the testis-specific N-terminus, resulting in infertile HSL-/-muttg mice. The other transgene expresses catalytically inactive enzyme with the testis-specific N-terminal peptide, resulting in HSL-/-atg mice. Infertile HSL-/-muttg mice show abnormal histology of the seminiferous epithelium and absence of spermatozoa in the epididymal lumen. In contrast, HSL-/-atg mice have normal fertility and normal testicular morphology	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	gene Lipe	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
germ cell	postmeiotic germ cells express a specific HSL isoform that includes a 313 amino acid N-terminus encoded by a testis-specific exon T1	Mus musculus	-
testis	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
HSL	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	in male mice, deficiency of hormone sensitive lipase causes deficient spermatogenesis, azoospermia, and infertility	Mus musculus
physiological function	the catalytic function of hormone-sensitive lipase is essential for spermatogenesis in male mice, while the presence of the enzyme's N-terminal testis-specific fragment is not essential	Mus musculus

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Release 2023.1 (January 2023)