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Literature summary for 3.1.1.79 extracted from

  • Sekiya, M.; Osuga, J.; Yahagi, N.; Okazaki, H.; Tamura, Y.; Igarashi, M.; Takase, S.; Harada, K.; Okazaki, S.; Iizuka, Y.; Ohashi, K.; Yagyu, H.; Okazaki, M.; Gotoda, T.; Nagai, R.; Kadowaki, T.; Shimano, H.; Yamada, N.; Ishibashi, S.
    Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis (2008), J. Lipid Res., 49, 1829-1838.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
HSL(-/-) mice feeding with a high-cholesterol diet induces hepatic cholesteryl ester accumulation, show reduced activity of cholesteryl ester hydrolase, but not of TG lipase. Hepatocytes show reduced activity of cholesteryl ester hydrolase and contain more cholesteryl ester than those from HSL(+/+) mice even without the incubation with lipoproteins Mus musculus
Lep(ob/ob)/HSL(-/-) mice lacking both leptin and HSL (Lep(ob/ob)/HSL(-/-)) show massive accumulation of cholesteryl ester in the liver compared with Lep(ob/ob)/HSL(+/+) mice, while triacylglycerol accumulation was modest Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information incubation with LDL augments the accumulation of cholesteryl ester in the HSL-deficient hepatocytes Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Mus musculus
-
liver
-
Mus musculus
-
parenchymal cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesteryl ester + H2O
-
Mus musculus cholesterol + a carboxylate
-
?

Synonyms

Synonyms Comment Organism
hormone-sensitive lipase
-
Mus musculus
HSL
-
Mus musculus