Protein Variants | Comment | Organism |
---|---|---|
HSL(-/-) mice | feeding with a high-cholesterol diet induces hepatic cholesteryl ester accumulation, show reduced activity of cholesteryl ester hydrolase, but not of TG lipase. Hepatocytes show reduced activity of cholesteryl ester hydrolase and contain more cholesteryl ester than those from HSL(+/+) mice even without the incubation with lipoproteins | Mus musculus |
Lep(ob/ob)/HSL(-/-) | mice lacking both leptin and HSL (Lep(ob/ob)/HSL(-/-)) show massive accumulation of cholesteryl ester in the liver compared with Lep(ob/ob)/HSL(+/+) mice, while triacylglycerol accumulation was modest | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | incubation with LDL augments the accumulation of cholesteryl ester in the HSL-deficient hepatocytes | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
parenchymal cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesteryl ester + H2O | - |
Mus musculus | cholesterol + a carboxylate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hormone-sensitive lipase | - |
Mus musculus |
HSL | - |
Mus musculus |