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Literature summary for 3.1.1.79 extracted from
- Induction of ABCA1 by overexpression of hormone-sensitive lipase in macrophages (2008), Biochem. Biophys. Res. Commun., 376, 111-115.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | useful for the prevention of atherosclerosis | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in 293A cells | Mus musculus |
| expressed in THP-1- cells | Mus musculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 84000 | - |
Western blot analysis | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| peritoneal macrophage | MPM | Mus musculus | - |
| RAW-264.7 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesteryl ester + H2O | overexpression of HSL increases the supply of free cholesterol as a ligand for liver X receptor, thereby stimulates the expression of ABCA1 gene in macrophages | Mus musculus | cholesterol + a carboxylate | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| hormone-sensitive lipase | - |
Mus musculus |
| HSL | - |
Mus musculus |
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Release 2023.1 (January 2023)
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