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BRENDA support

Literature summary for 3.1.1.79 extracted from

  • Ryden, M.; Jocken, J.; van Harmelen, V.; Dicker, A.; Hoffstedt, J.; Wiren, M.; Blomqvist, L.; Mairal, A.; Langin, D.; Blaak, E.; Arner, P.
    Comparative studies of the role of hormone-sensitive lipase and adipose triglyceride lipase in human fat cell lipolysis (2007), Am. J. Physiol. Endocrinol. Metab., 292, E1847-E1855.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information hormone-sensitive lipase is knocked down by RNA interference or selectively inhibited Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q05469
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Source Tissue

Source Tissue Comment Organism Textmining
adipocyte women with polycystic ovary syndrome or obesity have significantly decreased expression of hormone-sensitive lipase. Knock down of hormone-sensitive lipase by RNAi reduces basal and catecholamine-induced lipolysis. Treatment of mesenchymal stem cells with a selective inhibitor of hormone-sensitive lipase during and/or after differentiation in adipocytes reduces basal lipolysis by 50% Homo sapiens
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