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Literature summary for 3.1.1.79 extracted from

  • Donsmark, M.; Langfort, J.; Holm, C.; Ploug, T.; Galbo, H.
    Regulation and role of hormone-sensitive lipase in rat skeletal muscle (2004), Proc. Nutr. Soc., 63, 309-314.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus expressed at a higher level in oxidative fibres than in glycolytic fibres. The two physiological stimuli adrenaline and contraction increase enzyme activity in muscle, and the effects are partially additive. Adrenaline acts via beta-adrenergic activation of cAMP-dependent protein kinase, while the effect of contractions is mediated by protein kinase C, at least partly via the extracellular signal-regulated kinase pathway. Endurance training diminishes the sensitivity of muscle hormone-sensitive lipase to adrenaline but increases the contraction-mediated activation ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
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 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle expressed at a higher level in oxidative fibres than in glycolytic fibres. The two physiological stimuli adrenaline and contraction increase enzyme activity in muscle, and the effects are partially additive. Adrenaline acts via beta-adrenergic activation of cAMP-dependent protein kinase, while the effect of contractions is mediated by protein kinase C, at least partly via the extracellular signal-regulated kinase pathway. Endurance training diminishes the sensitivity of muscle hormone-sensitive lipase to adrenaline but increases the contraction-mediated activation Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information expressed at a higher level in oxidative fibres than in glycolytic fibres. The two physiological stimuli adrenaline and contraction increase enzyme activity in muscle, and the effects are partially additive. Adrenaline acts via beta-adrenergic activation of cAMP-dependent protein kinase, while the effect of contractions is mediated by protein kinase C, at least partly via the extracellular signal-regulated kinase pathway. Endurance training diminishes the sensitivity of muscle hormone-sensitive lipase to adrenaline but increases the contraction-mediated activation Rattus norvegicus ?
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 ?