Literature summary for 3.1.1.77 extracted from

Zou, B.; Jiang, W.; Han, H.; Li, J.; Mao, W.; Tang, Z.; Yang, Q.; Qian, G.; Qian, J.; Zeng, W.; Gu, J.; Chu, T.; Zhu, N.; Zhang, W.; Yan, D.; He, R.; Chu, Y.; Lu, M.
Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury (2017), PLoS Pathog., 13, e1006436 .

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Application

Application	Comment	Organism
medicine	alveolar macrophages increase AOAH expression upon exposure to lipopolysaccharide and Aoah+/+ mice recover more rapidly than Aoah-/- mice from acute lung injury induced by nasally instilled lipopolysaccharide or Klebsiella pneumoniae. Aoah-/- mouse lungs have more prolonged leukocyte infiltration, greater pro- and anti-inflammatory cytokine expression, and longer lasting alveolar barrier damage. The persistently bioactive lipopolysaccharide in Aoah-/- alveoli can stimulate alveolar macrophages directly and epithelial cells indirectly to produce chemoattractants that recruit neutrophils to the lung and may prevent their clearance. Alveolar macrophages that lack AOAH maintain or increase their responses to bioactive lipopolysaccharides and sustained inflammation	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O35298	-	-

General Information

General Information	Comment	Organism
physiological function	alveolar macrophages increase Aoah expression upon exposure to lipopolysaccharide and Aoah+/+ mice recover more rapidly than Aoah-/- mice from acute lung injury induced by nasally instilled lipopolysaccharide or Klebsiella pneumoniae. Aoah-/- mouse lungs have more prolonged leukocyte infiltration, greater pro- and anti-inflammatory cytokine expression, and longer lasting alveolar barrier damage. The persistently bioactive lipopolysaccharide in Aoah-/- alveoli can stimulate alveolar macrophages directly and epithelial cells indirectly to produce chemoattractants that recruit neutrophils to the lung and may prevent their clearance. Alveolar macrophages that lack AOAH maintain or increase their responses to bioactive lipopolysaccharides and sustained inflammation	Mus musculus

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Release 2023.1 (January 2023)