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Literature summary for 3.1.1.77 extracted from

  • Janelsins, B.M.; Lu, M.; Datta, S.K.
    Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity (2014), Proc. Natl. Acad. Sci. USA, 111, 373-378.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme inactivates lipopolysaccharides deacylating secondary fatty acyl chains on the lipid A moiety of lipopolysaccharide ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
colon
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Mus musculus
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dendritic cell colonic Mus musculus
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lamina propria of both the colon and small intestines Mus musculus
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T-lymphocyte interleukin 17-secreting CD4+ helper T cells Mus musculus
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Th17 cell
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme inactivates lipopolysaccharides deacylating secondary fatty acyl chains on the lipid A moiety of lipopolysaccharide Mus musculus ?
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?

Synonyms

Synonyms Comment Organism
AOAH
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Mus musculus

General Information

General Information Comment Organism
malfunction acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 polarization and immunity due to altered inactivation of commensal lipopolysaccharides. Lipopolysaccharide-containing Gram-negative microbiota augment the differentiation of antigen-specific Th17 cells Mus musculus
physiological function acyloxyacyl hydrolase is a mammalian enzyme expressed by antigen-presenting cells that deacylates and thereby inactivates lipopolysaccharide in host tissues. Deacylated lipopolysaccharide does not activate TLR4 and competitively inhibits signaling by biologically active lipopolysaccharide. The enzyme shows ability to modulate microbial signals that influence mucosal T cell immunity. Colonic dendritic cell subset (CD103+CD11beta+ALDH-) display a unique capacity to both express the enzyme and polarize interleukin 17-secreting CD4+ helper T cells, Th17 cells Mus musculus