Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the enzyme inactivates lipopolysaccharides deacylating secondary fatty acyl chains on the lipid A moiety of lipopolysaccharide | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Mus musculus | - |
dendritic cell | colonic | Mus musculus | - |
lamina propria | of both the colon and small intestines | Mus musculus | - |
T-lymphocyte | interleukin 17-secreting CD4+ helper T cells | Mus musculus | - |
Th17 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme inactivates lipopolysaccharides deacylating secondary fatty acyl chains on the lipid A moiety of lipopolysaccharide | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AOAH | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 polarization and immunity due to altered inactivation of commensal lipopolysaccharides. Lipopolysaccharide-containing Gram-negative microbiota augment the differentiation of antigen-specific Th17 cells | Mus musculus |
physiological function | acyloxyacyl hydrolase is a mammalian enzyme expressed by antigen-presenting cells that deacylates and thereby inactivates lipopolysaccharide in host tissues. Deacylated lipopolysaccharide does not activate TLR4 and competitively inhibits signaling by biologically active lipopolysaccharide. The enzyme shows ability to modulate microbial signals that influence mucosal T cell immunity. Colonic dendritic cell subset (CD103+CD11beta+ALDH-) display a unique capacity to both express the enzyme and polarize interleukin 17-secreting CD4+ helper T cells, Th17 cells | Mus musculus |