Literature summary for 3.1.1.77 extracted from

Shao, B.; Kitchens, R.; Munford, R.; Rogers, T.; Rockey, D.; Varley, A.
Prolonged hepatomegaly in mice that cannot inactivate bacterial endotoxin (2011), Hepatology, 54, 1051-1062.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
AOAH	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	Aoah-/- mice with low doses of bacterial lipopolysaccharide, from from Escherichia coli strain O14, or Gram-negative bacteria have livers remaining enlarged, as much as 80% above normal, many weeks longer than do the livers of Aoah+/+ animals. When compared with livers from bacterial lipopolysaccharide-primed Aoah+/+ mice, bacterial lipopolysaccharide-primed Aoah-/- livers have more numerous and larger Kupffer cells, intrasinusoidal leukocyte aggregates and activated sinusoidal endothelial cells, and sustained production of interleukin-10 and mRNAs for tumor necrosis factor, interleukin-10, and IRAKM, phenotype, overview	Mus musculus
physiological function	bacterial lipopolysaccharide, from Escherichia coli strain O14, induce hepatomegaly in mice, a recovery requires the murine enzyme, acyloxyacyl hydrolase, that inactivates bacterial lipopolysaccharide, overview	Mus musculus

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Release 2023.1 (January 2023)