Application | Comment | Organism |
---|---|---|
medicine | constitutive overexpression of AOAH in vivo hasten recovery from lipopolysaccharide exposure without interfering with the normal acute inflammatory response | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-(acyloxy)acyl group of bacterial toxin + H2O | detoxification of lipopolysaccharide | Mus musculus | 3-hydroxyacyl group of bacterial toxin + a fatty acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AOAH | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | transgenic mice overexpressing AOAH in dendritic cells and macrophages deacylate lipopolysaccharide more rapidly than wildtype controls. Transgenic mice are also protected from lipopolysaccharide-induced hepatosplenomegaly, recover more quickly from lipopolysaccharide-induced weight loss, and are more likely to survive when challenged with live Escherichia coli | Mus musculus |