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Literature summary for extracted from

  • Ojogun, N.; Kuang, T.Y.; Shao, B.; Greaves, D.R.; Munford, R.S.; Varley, A.W.
    Overproduction of acyloxyacyl hydrolase by macrophages and dendritic cells prevents prolonged reactions to bacterial lipopolysaccharide in vivo (2009), J. Infect. Dis., 200, 1685-1693.
    View publication on PubMedView publication on EuropePMC


Application Comment Organism
medicine constitutive overexpression of AOAH in vivo hasten recovery from lipopolysaccharide exposure without interfering with the normal acute inflammatory response Mus musculus


Organism UniProt Comment Textmining
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin + H2O detoxification of lipopolysaccharide Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid


Synonyms Comment Organism
Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
assay at Mus musculus

General Information

General Information Comment Organism
malfunction transgenic mice overexpressing AOAH in dendritic cells and macrophages deacylate lipopolysaccharide more rapidly than wildtype controls. Transgenic mice are also protected from lipopolysaccharide-induced hepatosplenomegaly, recover more quickly from lipopolysaccharide-induced weight loss, and are more likely to survive when challenged with live Escherichia coli Mus musculus