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Literature summary for 3.1.1.77 extracted from

  • Shao, B.; Lu, M.; Katz, S.C.; Varley, A.W.; Hardwick, J.; Rogers, T.E.; Ojogun, N.; Rockey, D.C.; Dematteo, R.P.; Munford, R.S.
    A host lipase detoxifies bacterial lipopolysaccharides in the liver and spleen (2007), J. Biol. Chem., 282, 13726-13735.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin + H2O Mus musculus host AOAH selectively removes the secondary fatty acyl chains from bacterial lipopolysaccharides, that are required for lipopolysaccharide recognition by its mammalian signaling receptor, MD-2-TLR4. Possibility that AOAH, by inactivating bacterial lipopolysaccharide within the liver and spleen, is an important endogenous control mechanism. Recombinant AOAH restores hepatic LPS deacylation and prevented LPS-induced hepatomegaly in Aoah-/- mice 3-hydroxyacyl group of bacterial toxin + a fatty acid
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Organism

Organism UniProt Comment Textmining
Mus musculus O35298
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Source Tissue

Source Tissue Comment Organism Textmining
Kupffer cell
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin + H2O host AOAH selectively removes the secondary fatty acyl chains from bacterial lipopolysaccharides, that are required for lipopolysaccharide recognition by its mammalian signaling receptor, MD-2-TLR4. Possibility that AOAH, by inactivating bacterial lipopolysaccharide within the liver and spleen, is an important endogenous control mechanism. Recombinant AOAH restores hepatic LPS deacylation and prevented LPS-induced hepatomegaly in Aoah-/- mice Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid
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Synonyms

Synonyms Comment Organism
AOAH
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Mus musculus