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Literature summary for 3.1.1.77 extracted from

  • Staab, J.F.; Fosmire, S.; Zhang, M.; Varley, A.W.; Munford, R.S.
    Distinctive structural features are shared by human, lapine, and murine acloxyacyl hydrolases (1999), J. Endotoxin Res., 5, 205-208.
No PubMed abstract available

Cloned(Commentary)

Cloned (Comment) Organism
in BHK 570 cells Mus musculus
in BHK 570 cells Homo sapiens
in BHK 570 cells Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
lipopolysaccharide
-
Mus musculus
0.0005
-
lipopolysaccharide
-
Oryctolagus cuniculus
0.0006
-
lipopolysaccharide
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin Mus musculus detoxification of LPS 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?
3-(acyloxy)acyl group of bacterial toxin Homo sapiens detoxification of LPS 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?
3-(acyloxy)acyl group of bacterial toxin Oryctolagus cuniculus detoxification of LPS 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens
glycoprotein small subunit not glycosylated Mus musculus
glycoprotein only three glycosylation sites in large subunit Mus musculus
glycoprotein only three glycosylation sites in large subunit Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?
3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?
3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Oryctolagus cuniculus 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
-
Mus musculus 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
-
Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
-
Oryctolagus cuniculus 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?
lipopolysaccharide + H2O
-
Mus musculus ?
-
?
lipopolysaccharide + H2O
-
Homo sapiens ?
-
?
lipopolysaccharide + H2O
-
Oryctolagus cuniculus ?
-
?

Subunits

Subunits Comment Organism
dimer disufide linked hetrodimer Mus musculus
dimer disufide linked hetrodimer Homo sapiens
dimer disufide linked hetrodimer Oryctolagus cuniculus