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Literature summary for 3.1.1.77 extracted from

  • Staab, J.F.; Ginkel, D.L.; Rosenberg, G.B.; Munford, R.S.
    A saposin-like domain influences the intracellular localization, stability, and catalytic activity of human acyloxyacyl hydrolase (1994), J. Biol. Chem., 269, 23736-23742.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
SDS-PAGE, large subunit Homo sapiens
14000
-
SDS-PAGE, small subunit Homo sapiens
7900 8100 SDS-PAGE of deglycosylated small subunit Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin Homo sapiens detoxification of LPS 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein glycosylation of the small subunit not essential for activity Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin + H2O
-
Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?
3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?

Subunits

Subunits Comment Organism
dimer 1 * 14000 + 1 * 52000, small subunit not required for activity Homo sapiens