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Literature summary for 3.1.1.77 extracted from

  • Munford, R.S.; Hunter, J.P.
    Acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides, has phospholipase, lysophospholipase, diacylglycerollipase, and acyltransferase activities in vitro (1992), J. Biol. Chem., 267, 10116-10121.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol
-
Homo sapiens
Triton X-100
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-mercaptoethanol
-
Homo sapiens
diisopropylfluorophosphate
-
Homo sapiens
p-bromophenacylbromide
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00036
-
diacylphosphatidylethanolamine
-
Homo sapiens
0.00167
-
lipopolysaccharide
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin Homo sapiens detoxification of LPS 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?
3-(acyloxy)acyl group of bacterial toxin + H2O
-
Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?
diacylglycerol + H2O in vitro Homo sapiens ?
-
?
diacylphosphatidylethanolamine + H2O
-
Homo sapiens ?
-
?
glycerophospholipid + H2O in vitro Homo sapiens ?
-
?
lipopolysaccharide + H2O
-
Homo sapiens ?
-
?
lysophospholipid + H2O in vitro Homo sapiens ?
-
?
additional information different lipids as substrates Homo sapiens ?
-
?
sn-1,2-dipalmitoylglycerol + H2O in vitro Homo sapiens palmitate + glycerol
-
?
sn-1,2-dipalmitoylphosphatidylcholine + H2O in vitro Homo sapiens palmitate + phosphatidylcholine
-
?

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
from acid to neutral pH Homo sapiens