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Literature summary for 3.1.1.77 extracted from

  • Hagen, F.S.; Grant, F.J.; Kuijper, J.L.; Slaughter, C.A.; Moomaw, C.R.; Orth, K.; O'Hara, P.J.; Munford, R.S.
    Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides (1991), Biochemistry, 30, 8415-8423.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
in BHK 570 cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
large subunit, SDS-PAGE in presence of 2-mercaptoethanol Homo sapiens
47700
-
large subunit, calculated from sequence of unglycosylated protein Homo sapiens
13800
-
small subunit, calculated from sequence of unglycosylated protein Homo sapiens
14000 20000 small subunit, SDS-PAGE in presence of 2-mercaptoethanol Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin Homo sapiens detoxification of LPS 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein five potential glycosylation sites, one on the small and four on the large subunit Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin + H2O
-
Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?
3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?

Subunits

Subunits Comment Organism
dimer alpha, beta, 1 * 50000 + 1 * 14000-20000, disulfide linked Homo sapiens