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Literature summary for 3.1.1.77 extracted from

  • Erwin, A.L.; Munford, R.S.
    Deacylation of structurally diverse lipopolysaccharides by human acyloxyacyl hydrolase (1990), J. Biol. Chem., 265, 16444-16449.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100 required Homo sapiens

Application

Application Comment Organism
analysis potential use in studies of LPS structure and bioactivity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00026
-
long chain lipopolysaccharide
-
Homo sapiens
0.00031
-
medium chain lipopolysaccharide
-
Homo sapiens
0.00032
-
short chain lipopolysaccharide
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ CaCl2 enhances activity at pH 4.8 by 1.5-2 fold Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin Homo sapiens detoxification of LPS 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(acyloxy)acyl group of bacterial toxin + H2O smooth LPS deacylated more slowly than rough LPS Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid palmitoleate released more slowly than myristate and laurate, 2-hydroxylaurate released more slowly than laurate ?
3-(acyloxy)acyl group of bacterial toxin detoxification of LPS Homo sapiens 3-hydroxyacyl group of bacterial toxin + a fatty acid
-
?
long chain lipopolysaccharide + H2O
-
Homo sapiens ?
-
?
medium chain lipopolysaccharide + H2O
-
Homo sapiens ?
-
?
short chain lipopolysaccharide + H2O
-
Homo sapiens ?
-
?