Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BW284c51 | a specific inhibitor of AChE, strongly inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM | Mytilus galloprovincialis | |
BW284c51 | a specific inhibitor of AChE, strongly inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM | Perforatus perforatus | |
BW284c51 | a specific inhibitor of AChE, moderately inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM | Pollicipes pollicipes | |
Cu2+ | slight inhibition of ChE activity at 0.0125-0.4 mM | Mytilus galloprovincialis | |
Cu2+ | slight inhibition of ChE activity at 0.0125-0.4 mM | Pollicipes pollicipes | |
eserine | a nonspecific inhibitor of ChEs, strongly inhibits the ChE activity at all concentrations tested, 0.00625-0.2 mM | Mytilus galloprovincialis | |
eserine | a nonspecific inhibitor of ChEs, strongly inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM | Perforatus perforatus | |
eserine | a nonspecific inhibitor of ChEs, moderately inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM | Pollicipes pollicipes | |
additional information | for tetra(monoisopropyl)diphosphortetramide (iso-OMPA), a specific inhibitor for BuChE, no inhibition of ChE activity is observed at any concentration tested, 0.25-8.0 mM. Cyanobacterial extracts with AChE inhibition and induction potential, overview | Mytilus galloprovincialis | |
additional information | for tetra(monoisopropyl)diphosphortetramide (iso-OMPA), a specific inhibitor for BuChE, no inhibition of ChE activity is observed at any concentration tested, 0.25-8.0 mM. Cu2+ is a poor inhibitor of ChE activity at 0.0125-0.4 mM. Cyanobacterial extracts with AChE inhibition and induction potential, overview | Perforatus perforatus | |
additional information | for tetra(monoisopropyl)diphosphortetramide (iso-OMPA), a specific inhibitor for BuChE, no inhibition of ChE activity is observed at any concentration tested, 0.25-8.0 mM. Cyanobacterial extracts with AChE inhibition and induction potential, overview | Pollicipes pollicipes |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Michaelis-Menten kinetic modelling | Mytilus galloprovincialis | |
additional information | - |
additional information | Michaelis-Menten kinetic modelling | Pollicipes pollicipes | |
additional information | - |
additional information | Michaelis-Menten kinetic modelling | Perforatus perforatus | |
0.00289 | - |
butyrylthiocholine | pH 7.2, 25°C | Mytilus galloprovincialis | |
0.01404 | - |
acetyl-beta-methylthiocholine | pH 7.2, 25°C | Mytilus galloprovincialis | |
0.02218 | - |
acetylthiocholine | pH 7.2, 25°C | Mytilus galloprovincialis | |
0.02297 | - |
acetylthiocholine | pH 7.2, 25°C | Pollicipes pollicipes | |
0.03607 | - |
propionylthiocholine | pH 7.2, 25°C | Mytilus galloprovincialis | |
0.09681 | - |
acetyl-beta-methylthiocholine | pH 7.2, 25°C | Pollicipes pollicipes | |
0.2206 | - |
acetyl-beta-methylthiocholine | pH 7.2, 25°C | Perforatus perforatus | |
0.2359 | - |
acetylthiocholine | pH 7.2, 25°C | Perforatus perforatus | |
1.418 | - |
butyrylthiocholine | pH 7.2, 25°C | Perforatus perforatus | |
3.717 | - |
propionylthiocholine | pH 7.2, 25°C | Pollicipes pollicipes | |
27.912 | - |
propionylthiocholine | pH 7.2, 25°C | Perforatus perforatus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Mytilus galloprovincialis | - |
choline + acetate | - |
? | |
acetylcholine + H2O | Pollicipes pollicipes | - |
choline + acetate | - |
? | |
acetylcholine + H2O | Perforatus perforatus | - |
choline + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mytilus galloprovincialis | - |
- |
- |
Perforatus perforatus | - |
Balanus perforatus | - |
Pollicipes pollicipes | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
foot | - |
Mytilus galloprovincialis | - |
muscle | - |
Mytilus galloprovincialis | - |
shell capitulum | - |
Pollicipes pollicipes | - |
soft body part | - |
Pollicipes pollicipes | - |
soft body part | - |
Perforatus perforatus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-beta-methylthiocholine + H2O | - |
Mytilus galloprovincialis | beta-methylthiocholine + acetate | - |
? | |
acetyl-beta-methylthiocholine + H2O | - |
Perforatus perforatus | beta-methylthiocholine + acetate | - |
? | |
acetyl-beta-methylthiocholine + H2O | preferred substrate | Pollicipes pollicipes | beta-methylthiocholine + acetate | - |
? | |
acetylcholine + H2O | - |
Mytilus galloprovincialis | choline + acetate | - |
? | |
acetylcholine + H2O | - |
Pollicipes pollicipes | choline + acetate | - |
? | |
acetylcholine + H2O | - |
Perforatus perforatus | choline + acetate | - |
? | |
acetylcholine + H2O | preferred substrate | Perforatus perforatus | choline + acetate | - |
? | |
acetylthiocholine + H2O | - |
Pollicipes pollicipes | thiocholine + acetate | - |
? | |
acetylthiocholine + H2O | preferred substrate | Mytilus galloprovincialis | thiocholine + acetate | - |
? | |
acetylthiocholine + H2O | preferred substrate | Perforatus perforatus | thiocholine + acetate | - |
? | |
butyrylthiocholine + H2O | very low activity | Mytilus galloprovincialis | thiocholine + butyrate | - |
? | |
butyrylthiocholine + H2O | low activity | Perforatus perforatus | thiocholine + butyrate | - |
? | |
additional information | Mytilus galloprovincialis ChE degrades preferentially acetylthiocholine (AcSCh), followed by acetyl-beta-methylthiocholine (AbSCh) and propionylthiocholine (PrSCh), while butyrylthiocholine (BuSCh) is poorly hydrolysed. About 9% to 10% of the ChE activity observed, with AcSCh as substrate, is probably due to other esterases (CoEs) activity | Mytilus galloprovincialis | ? | - |
? | |
additional information | Perforatus perforatus ChE degrades preferentially acetylthiocholine (AcSCh), and acetyl-beta-methylthiocholine (AbSCh), followed by propionylthiocholine (PrSCh), and shows only low activity with butyrylthiocholine (BuSCh) | Perforatus perforatus | ? | - |
? | |
additional information | Pollicipes pollicipes ChE degrades preferentially propionylthiocholine (PrSCh), followed by acetyl-beta-methylthiocholine (AbSCh) and acetylthiocholine (AcSCh), while butyrylthiocholine (BuSCh) is not hydrolysed | Pollicipes pollicipes | ? | - |
? | |
propionylthiocholine + H2O | - |
Mytilus galloprovincialis | thiocholine + propionate | - |
? | |
propionylthiocholine + H2O | - |
Pollicipes pollicipes | thiocholine + propionate | - |
? | |
propionylthiocholine + H2O | - |
Perforatus perforatus | thiocholine + propionate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Mytilus galloprovincialis |
AChE | - |
Pollicipes pollicipes |
AChE | - |
Perforatus perforatus |
ChE | - |
Mytilus galloprovincialis |
ChE | - |
Pollicipes pollicipes |
ChE | - |
Perforatus perforatus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Mytilus galloprovincialis |
25 | - |
assay at | Pollicipes pollicipes |
25 | - |
assay at | Perforatus perforatus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Mytilus galloprovincialis |
7.2 | - |
assay at | Pollicipes pollicipes |
7.2 | - |
assay at | Perforatus perforatus |