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Literature summary for 3.1.1.7 extracted from

  • Almeida, J.R.; Freitas, M.; Cruz, S.; Leao, P.N.; Vasconcelos, V.; Cunha, I.
    Acetylcholinesterase in biofouling species characterization and mode of action of cyanobacteria-derived antifouling agents (2015), Toxins, 7, 2739-2756 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
BW284c51 a specific inhibitor of AChE, strongly inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM Mytilus galloprovincialis
BW284c51 a specific inhibitor of AChE, strongly inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM Perforatus perforatus
BW284c51 a specific inhibitor of AChE, moderately inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM Pollicipes pollicipes
Cu2+ slight inhibition of ChE activity at 0.0125-0.4 mM Mytilus galloprovincialis
Cu2+ slight inhibition of ChE activity at 0.0125-0.4 mM Pollicipes pollicipes
eserine a nonspecific inhibitor of ChEs, strongly inhibits the ChE activity at all concentrations tested, 0.00625-0.2 mM Mytilus galloprovincialis
eserine a nonspecific inhibitor of ChEs, strongly inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM Perforatus perforatus
eserine a nonspecific inhibitor of ChEs, moderately inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM Pollicipes pollicipes
additional information for tetra(monoisopropyl)diphosphortetramide (iso-OMPA), a specific inhibitor for BuChE, no inhibition of ChE activity is observed at any concentration tested, 0.25-8.0 mM. Cyanobacterial extracts with AChE inhibition and induction potential, overview Mytilus galloprovincialis
additional information for tetra(monoisopropyl)diphosphortetramide (iso-OMPA), a specific inhibitor for BuChE, no inhibition of ChE activity is observed at any concentration tested, 0.25-8.0 mM. Cu2+ is a poor inhibitor of ChE activity at 0.0125-0.4 mM. Cyanobacterial extracts with AChE inhibition and induction potential, overview Perforatus perforatus
additional information for tetra(monoisopropyl)diphosphortetramide (iso-OMPA), a specific inhibitor for BuChE, no inhibition of ChE activity is observed at any concentration tested, 0.25-8.0 mM. Cyanobacterial extracts with AChE inhibition and induction potential, overview Pollicipes pollicipes

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Michaelis-Menten kinetic modelling Mytilus galloprovincialis
additional information
-
additional information Michaelis-Menten kinetic modelling Pollicipes pollicipes
additional information
-
additional information Michaelis-Menten kinetic modelling Perforatus perforatus
0.00289
-
butyrylthiocholine pH 7.2, 25°C Mytilus galloprovincialis
0.01404
-
acetyl-beta-methylthiocholine pH 7.2, 25°C Mytilus galloprovincialis
0.02218
-
acetylthiocholine pH 7.2, 25°C Mytilus galloprovincialis
0.02297
-
acetylthiocholine pH 7.2, 25°C Pollicipes pollicipes
0.03607
-
propionylthiocholine pH 7.2, 25°C Mytilus galloprovincialis
0.09681
-
acetyl-beta-methylthiocholine pH 7.2, 25°C Pollicipes pollicipes
0.2206
-
acetyl-beta-methylthiocholine pH 7.2, 25°C Perforatus perforatus
0.2359
-
acetylthiocholine pH 7.2, 25°C Perforatus perforatus
1.418
-
butyrylthiocholine pH 7.2, 25°C Perforatus perforatus
3.717
-
propionylthiocholine pH 7.2, 25°C Pollicipes pollicipes
27.912
-
propionylthiocholine pH 7.2, 25°C Perforatus perforatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Mytilus galloprovincialis
-
choline + acetate
-
?
acetylcholine + H2O Pollicipes pollicipes
-
choline + acetate
-
?
acetylcholine + H2O Perforatus perforatus
-
choline + acetate
-
?

Organism

Organism UniProt Comment Textmining
Mytilus galloprovincialis
-
-
-
Perforatus perforatus
-
Balanus perforatus
-
Pollicipes pollicipes
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
foot
-
Mytilus galloprovincialis
-
muscle
-
Mytilus galloprovincialis
-
shell capitulum
-
Pollicipes pollicipes
-
soft body part
-
Pollicipes pollicipes
-
soft body part
-
Perforatus perforatus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-beta-methylthiocholine + H2O
-
Mytilus galloprovincialis beta-methylthiocholine + acetate
-
?
acetyl-beta-methylthiocholine + H2O
-
Perforatus perforatus beta-methylthiocholine + acetate
-
?
acetyl-beta-methylthiocholine + H2O preferred substrate Pollicipes pollicipes beta-methylthiocholine + acetate
-
?
acetylcholine + H2O
-
Mytilus galloprovincialis choline + acetate
-
?
acetylcholine + H2O
-
Pollicipes pollicipes choline + acetate
-
?
acetylcholine + H2O
-
Perforatus perforatus choline + acetate
-
?
acetylcholine + H2O preferred substrate Perforatus perforatus choline + acetate
-
?
acetylthiocholine + H2O
-
Pollicipes pollicipes thiocholine + acetate
-
?
acetylthiocholine + H2O preferred substrate Mytilus galloprovincialis thiocholine + acetate
-
?
acetylthiocholine + H2O preferred substrate Perforatus perforatus thiocholine + acetate
-
?
butyrylthiocholine + H2O very low activity Mytilus galloprovincialis thiocholine + butyrate
-
?
butyrylthiocholine + H2O low activity Perforatus perforatus thiocholine + butyrate
-
?
additional information Mytilus galloprovincialis ChE degrades preferentially acetylthiocholine (AcSCh), followed by acetyl-beta-methylthiocholine (AbSCh) and propionylthiocholine (PrSCh), while butyrylthiocholine (BuSCh) is poorly hydrolysed. About 9% to 10% of the ChE activity observed, with AcSCh as substrate, is probably due to other esterases (CoEs) activity Mytilus galloprovincialis ?
-
?
additional information Perforatus perforatus ChE degrades preferentially acetylthiocholine (AcSCh), and acetyl-beta-methylthiocholine (AbSCh), followed by propionylthiocholine (PrSCh), and shows only low activity with butyrylthiocholine (BuSCh) Perforatus perforatus ?
-
?
additional information Pollicipes pollicipes ChE degrades preferentially propionylthiocholine (PrSCh), followed by acetyl-beta-methylthiocholine (AbSCh) and acetylthiocholine (AcSCh), while butyrylthiocholine (BuSCh) is not hydrolysed Pollicipes pollicipes ?
-
?
propionylthiocholine + H2O
-
Mytilus galloprovincialis thiocholine + propionate
-
?
propionylthiocholine + H2O
-
Pollicipes pollicipes thiocholine + propionate
-
?
propionylthiocholine + H2O
-
Perforatus perforatus thiocholine + propionate
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Mytilus galloprovincialis
AChE
-
Pollicipes pollicipes
AChE
-
Perforatus perforatus
ChE
-
Mytilus galloprovincialis
ChE
-
Pollicipes pollicipes
ChE
-
Perforatus perforatus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Mytilus galloprovincialis
25
-
assay at Pollicipes pollicipes
25
-
assay at Perforatus perforatus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Mytilus galloprovincialis
7.2
-
assay at Pollicipes pollicipes
7.2
-
assay at Perforatus perforatus