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Literature summary for 3.1.1.7 extracted from

  • Freitas, T.R.; Danuello, A.; Viegas Junior, C.; Bolzani, V.S.; Pivatto, M.
    Mass spectrometry for characterization of homologous piperidine alkaloids and their activity as acetylcholinesterase inhibitors (2018), Rapid Commun. Mass Spectrom., 32, 1303-1310 .
    View publication on PubMed

Application

Application Comment Organism
medicine acetylcholinesterase (AChE) inhibition is the standard therapy for Alzheimer's disease (AD), a late-onset neurodegenerative pathology that impacts an individual's memory, motor coordination, and cognition in a progressive and eventually lethal manner. Alzheimer's disease has huge socioeconomic impact, and healthcare research in the twenty-first century has prioritized the development of therapeutic alternatives to treat this condition Electrophorus electricus

Inhibitors

Inhibitors Comment Organism Structure
(-)-3-O-acetylcassine a semisynthetic alkaloid structure and stereochemistry by ESI-MS/MS and EI-MS Electrophorus electricus
(-)-3-O-acetylspectaline a semisynthetic alkaloid structure and stereochemistry by ESI-MS/MS and EI-MS Electrophorus electricus
(-)-cassine a piperidine alkaloid isolated from Senna spectabilis flowers, structure and stereochemistry by ESI-MS/MS and EI-MS Electrophorus electricus
(-)-spectaline a piperidine alkaloid isolated from Senna spectabilis flowers, structure and stereochemistry by ESI-MS/MS and EI-MS Electrophorus electricus
additional information mass spectrometric analysis and inhibitory potency of homologous piperidine alkaloids as acetylcholinesterase inhibitors, overview. Besides other aspects, the 2-methyl-3-hydroxypiperidine moiety is an important interaction site for the observed activity Electrophorus electricus
physostigmine
-
Electrophorus electricus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Electrophorus electricus
-
choline + acetate
-
?

Organism

Organism UniProt Comment Textmining
Electrophorus electricus O42275
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
Electrophorus electricus choline + acetate
-
?
acetylthiocholine + H2O
-
Electrophorus electricus thiocholine + acetate
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Electrophorus electricus
AChE type V
-
Electrophorus electricus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Electrophorus electricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Electrophorus electricus