Application | Comment | Organism |
---|---|---|
medicine | acetylcholinesterase (AChE) inhibition is the standard therapy for Alzheimer's disease (AD), a late-onset neurodegenerative pathology that impacts an individual's memory, motor coordination, and cognition in a progressive and eventually lethal manner. Alzheimer's disease has huge socioeconomic impact, and healthcare research in the twenty-first century has prioritized the development of therapeutic alternatives to treat this condition | Electrophorus electricus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-3-O-acetylcassine | a semisynthetic alkaloid structure and stereochemistry by ESI-MS/MS and EI-MS | Electrophorus electricus | |
(-)-3-O-acetylspectaline | a semisynthetic alkaloid structure and stereochemistry by ESI-MS/MS and EI-MS | Electrophorus electricus | |
(-)-cassine | a piperidine alkaloid isolated from Senna spectabilis flowers, structure and stereochemistry by ESI-MS/MS and EI-MS | Electrophorus electricus | |
(-)-spectaline | a piperidine alkaloid isolated from Senna spectabilis flowers, structure and stereochemistry by ESI-MS/MS and EI-MS | Electrophorus electricus | |
additional information | mass spectrometric analysis and inhibitory potency of homologous piperidine alkaloids as acetylcholinesterase inhibitors, overview. Besides other aspects, the 2-methyl-3-hydroxypiperidine moiety is an important interaction site for the observed activity | Electrophorus electricus | |
physostigmine | - |
Electrophorus electricus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Electrophorus electricus | - |
choline + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Electrophorus electricus | O42275 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Electrophorus electricus | choline + acetate | - |
? | |
acetylthiocholine + H2O | - |
Electrophorus electricus | thiocholine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Electrophorus electricus |
AChE type V | - |
Electrophorus electricus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Electrophorus electricus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Electrophorus electricus |