Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2,2-triethyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1,2,3,4-tetrahydroacridin-9-amine | - |
Electrophorus electricus | |
1,2-diethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-(2-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-(2-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-(2-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1Hquinazolin-4-one | - |
Electrophorus electricus | |
1-(2-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-(2-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-(2-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-(2-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-(2-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-(4-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-(4-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-(4-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-(4-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-(4-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-(4-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-(4-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1--(4-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-benzyl-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-benzyl-2,2-diisobutyl-2,3-dihydro-1Hquinazolin-4-one | - |
Electrophorus electricus | |
1-benzyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-benzyl-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-benzyl-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-benzyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-benzyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-benzyl-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-ethyl-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-ethyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-ethyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-ethyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
1-ethyl-2-methyl-2-propyl -2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
2,3-dihydroquinazolin-4(1H)-one | - |
Electrophorus electricus | |
2-(4-chloro-phenyl)-1-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | - |
Electrophorus electricus | |
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one | - |
Electrophorus electricus | |
2-[(5-acetyl-6-methyl-4-phenyl-1,4-dihydropyrimidin-2-yl)sulfanyl]-N-phenylacetamide | - |
Electrophorus electricus | |
2-[[5-acetyl-6-methyl-4-(4-phenoxyphenyl)-1,4-dihydropyrimidin-2-yl]sulfanyl]-N-phenylacetamide | - |
Electrophorus electricus | |
3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate | - |
Electrophorus electricus | |
6,8-dibromo-2-(4-chlorophenyl)-2-methyl-2,3-dihydroquinazolin-4(1H)-one | - |
Electrophorus electricus | |
bistacrine | - |
Electrophorus electricus | |
donepezil | - |
Electrophorus electricus | |
galantamine | - |
Electrophorus electricus | |
additional information | synthesis, crystal structure determination, biological screening, and docking studies of N1-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases, structure-activity relationships, overview | Electrophorus electricus | |
N-[4-[4-(1,3-benzothiazol-2-yl)phenoxy]butyl]-6-chloro-1,2,3,4-tetrahydroacridin-9-amine | - |
Electrophorus electricus | |
tacrine-caffeic acid hybrid | - |
Electrophorus electricus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Electrophorus electricus | O42275 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Electrophorus electricus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylthiocholine + H2O | - |
Electrophorus electricus | thiocholine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Electrophorus electricus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0008 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-benzyl-2,2-diisobutyl-2,3-dihydro-1Hquinazolin-4-one | |
0.001 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(2-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0012 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(4-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0017 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-benzyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0018 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-benzyl-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0024 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(4-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0024 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1--(4-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0038 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(2-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0041 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(4-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0053 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-benzyl-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0064 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-benzyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0073 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(4-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0092 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(4-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0094 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-benzyl-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0118 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-benzyl-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | |
0.013 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(2-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0132 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(2-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0132 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(2-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1Hquinazolin-4-one | |
0.0161 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-ethyl-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0167 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-benzyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0186 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-ethyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0193 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(2-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0194 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(4-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0217 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1,2-diethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0218 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(2-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0229 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(2-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0232 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 2-(4-chloro-phenyl)-1-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0323 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-ethyl-2-methyl-2-propyl -2,3-dihydro-1H-quinazolin-4-one | |
0.0338 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-ethyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0391 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1,2,2-triethyl-2,3-dihydro-1H-quinazolin-4-one | |
0.0432 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-ethyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one | |
0.6 | - |
pH and temperature not specified in the publication | Electrophorus electricus | 1-(4-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one |