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Literature summary for 3.1.1.7 extracted from

  • Sultana, N.; Sarfraz, M.; Tanoli, S.T.; Akram, M.S.; Sadiq, A.; Rashid, U.; Tariq, M.I.
    Synthesis, crystal structure determination, biological screening and docking studies of N1-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases (2017), Bioorg. Chem., 72, 256-267 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,2,2-triethyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1,2,3,4-tetrahydroacridin-9-amine
-
Electrophorus electricus
1,2-diethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-(2-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-(2-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-(2-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1Hquinazolin-4-one
-
Electrophorus electricus
1-(2-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-(2-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-(2-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-(2-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-(2-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-(4-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-(4-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-(4-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-(4-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-(4-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-(4-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-(4-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1--(4-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-benzyl-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-benzyl-2,2-diisobutyl-2,3-dihydro-1Hquinazolin-4-one
-
Electrophorus electricus
1-benzyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-benzyl-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-benzyl-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-benzyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-benzyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-benzyl-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-ethyl-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-ethyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-ethyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-ethyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
1-ethyl-2-methyl-2-propyl -2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
2,3-dihydroquinazolin-4(1H)-one
-
Electrophorus electricus
2-(4-chloro-phenyl)-1-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
Electrophorus electricus
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
Electrophorus electricus
2-[(5-acetyl-6-methyl-4-phenyl-1,4-dihydropyrimidin-2-yl)sulfanyl]-N-phenylacetamide
-
Electrophorus electricus
2-[[5-acetyl-6-methyl-4-(4-phenoxyphenyl)-1,4-dihydropyrimidin-2-yl]sulfanyl]-N-phenylacetamide
-
Electrophorus electricus
3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate
-
Electrophorus electricus
6,8-dibromo-2-(4-chlorophenyl)-2-methyl-2,3-dihydroquinazolin-4(1H)-one
-
Electrophorus electricus
bistacrine
-
Electrophorus electricus
donepezil
-
Electrophorus electricus
galantamine
-
Electrophorus electricus
additional information synthesis, crystal structure determination, biological screening, and docking studies of N1-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases, structure-activity relationships, overview Electrophorus electricus
N-[4-[4-(1,3-benzothiazol-2-yl)phenoxy]butyl]-6-chloro-1,2,3,4-tetrahydroacridin-9-amine
-
Electrophorus electricus
tacrine-caffeic acid hybrid
-
Electrophorus electricus

Organism

Organism UniProt Comment Textmining
Electrophorus electricus O42275
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Electrophorus electricus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
Electrophorus electricus thiocholine + acetate
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Electrophorus electricus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0008
-
pH and temperature not specified in the publication Electrophorus electricus 1-benzyl-2,2-diisobutyl-2,3-dihydro-1Hquinazolin-4-one
0.001
-
pH and temperature not specified in the publication Electrophorus electricus 1-(2-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
0.0012
-
pH and temperature not specified in the publication Electrophorus electricus 1-(4-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0017
-
pH and temperature not specified in the publication Electrophorus electricus 1-benzyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0018
-
pH and temperature not specified in the publication Electrophorus electricus 1-benzyl-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
0.0024
-
pH and temperature not specified in the publication Electrophorus electricus 1-(4-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
0.0024
-
pH and temperature not specified in the publication Electrophorus electricus 1--(4-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
0.0038
-
pH and temperature not specified in the publication Electrophorus electricus 1-(2-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
0.0041
-
pH and temperature not specified in the publication Electrophorus electricus 1-(4-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
0.0053
-
pH and temperature not specified in the publication Electrophorus electricus 1-benzyl-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
0.0064
-
pH and temperature not specified in the publication Electrophorus electricus 1-benzyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
0.0073
-
pH and temperature not specified in the publication Electrophorus electricus 1-(4-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0092
-
pH and temperature not specified in the publication Electrophorus electricus 1-(4-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0094
-
pH and temperature not specified in the publication Electrophorus electricus 1-benzyl-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0118
-
pH and temperature not specified in the publication Electrophorus electricus 1-benzyl-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.013
-
pH and temperature not specified in the publication Electrophorus electricus 1-(2-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0132
-
pH and temperature not specified in the publication Electrophorus electricus 1-(2-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
0.0132
-
pH and temperature not specified in the publication Electrophorus electricus 1-(2-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1Hquinazolin-4-one
0.0161
-
pH and temperature not specified in the publication Electrophorus electricus 1-ethyl-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
0.0167
-
pH and temperature not specified in the publication Electrophorus electricus 1-benzyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
0.0186
-
pH and temperature not specified in the publication Electrophorus electricus 1-ethyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
0.0193
-
pH and temperature not specified in the publication Electrophorus electricus 1-(2-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0194
-
pH and temperature not specified in the publication Electrophorus electricus 1-(4-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
0.0217
-
pH and temperature not specified in the publication Electrophorus electricus 1,2-diethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0218
-
pH and temperature not specified in the publication Electrophorus electricus 1-(2-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
0.0229
-
pH and temperature not specified in the publication Electrophorus electricus 1-(2-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0232
-
pH and temperature not specified in the publication Electrophorus electricus 2-(4-chloro-phenyl)-1-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.0323
-
pH and temperature not specified in the publication Electrophorus electricus 1-ethyl-2-methyl-2-propyl -2,3-dihydro-1H-quinazolin-4-one
0.0338
-
pH and temperature not specified in the publication Electrophorus electricus 1-ethyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
0.0391
-
pH and temperature not specified in the publication Electrophorus electricus 1,2,2-triethyl-2,3-dihydro-1H-quinazolin-4-one
0.0432
-
pH and temperature not specified in the publication Electrophorus electricus 1-ethyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
0.6
-
pH and temperature not specified in the publication Electrophorus electricus 1-(4-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one