Any feedback?
Literature summary for 3.1.1.7 extracted from
- Kinetics and molecular docking studies of loganin, morroniside and 7-O-galloyl-D-sedoheptulose derived from Corni fructus as cholinesterase and beta-secretase 1 inhibitors (2016), Arch. Pharm. Res., 39, 794-805 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 7-O-galloyl-D-sedoheptulose | a mixed-type inhibitor, enzyme interacting residues, overview | Tetronarce californica |  |
| Berberine | - |
Tetronarce californica | |
| loganin | a mixed-type inhibitor, enzyme interacting residues, overview | Tetronarce californica | |
| additional information | kinetics and molecular docking studies of loganin, morroniside and 7-O-galloyl-D-sedoheptulose derived from Cornus officinalis fruits (Corni fructus) as cholinesterase and beta-secretase 1 inhibitors, overview | Tetronarce californica | |
| morroniside | a noncompetitive inhibitor, enzyme interacting residues, overview | Tetronarce californica | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | Tetronarce californica | - |
choline + acetate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Tetronarce californica | P04058 | i.e. Torpedo californica | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylcholine + H2O | - |
Tetronarce californica | choline + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BChE | - |
Tetronarce californica |
| butyrylcholinesterase | - |
Tetronarce californica |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01004 | - |
loganin | pH and temperature not specified in the publication | Tetronarce californica | |
| 0.01332 | - |
morroniside | pH and temperature not specified in the publication | Tetronarce californica | |
| 0.0183 | - |
7-O-galloyl-D-sedoheptulose | pH and temperature not specified in the publication | Tetronarce californica | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00033 | - |
pH and temperature not specified in the publication | Tetronarce californica | loganin | |
| 0.00045 | - |
pH and temperature not specified in the publication | Tetronarce californica | Berberine | |
| 0.00395 | - |
pH and temperature not specified in the publication | Tetronarce californica | morroniside | |
| 0.0105 | - |
pH and temperature not specified in the publication | Tetronarce californica | 7-O-galloyl-D-sedoheptulose | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
