Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-dodecyl-1H-pyrrole-2,5-dione | - |
Homo sapiens | |
2,2'-[[(E)-1,2-diphenylethene-1,2-diyl]bis(benzene-4,1-diyloxy)]diethanesulfonate | - |
Homo sapiens | |
donepezil | - |
Homo sapiens | |
additional information | the ensemble of compounds 1 and 2 can be used for the AChE activity assay and the inhibitor-screening by making use of the aggregation-induced emission feature of tetraphenyl ethylene compounds, method development, overview | Homo sapiens | |
neostigmine | - |
Homo sapiens | |
tacrine | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Homo sapiens | - |
acetate + choline | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain cortex | - |
Homo sapiens | - |
hippocampus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Homo sapiens | acetate + choline | - |
? | |
acetylthiocholine iodide + H2O | - |
Homo sapiens | acetate + thiocholine iodide | - |
? | |
additional information | the ensemble of compound 1 and compound 2 can be used for the AChE activity assay and the inhibitor-screening by making use of the aggregation-induced emission feature of tetraphenyl ethylene compounds, method development, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.3 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000064 | - |
pH 7.3 | Homo sapiens | donepezil | |
0.0000118 | - |
pH 7.3 | Homo sapiens | tacrine | |
0.0000503 | - |
pH 7.3 | Homo sapiens | neostigmine |
General Information | Comment | Organism |
---|---|---|
malfunction | Alzheimer's disease, a neurodegenerative disease characterized by a low concentration of acetylcholine in the hippocampus and cortex, is the leading cause of dementia among older people | Homo sapiens |
physiological function | hydrolysis of acetylcholine by acetylcholinesterase is a key process for the regulation of the neutral response system | Homo sapiens |