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Literature summary for 3.1.1.7 extracted from

  • Peng, L.; Zhang, G.; Zhang, D.; Xiang, J.; Zhao, R.; Wang, Y.; Zhu, D.
    A fluorescence turn-on ensemble for acetylcholinesterase activity assay and inhibitor screening (2009), Org. Lett., 11, 4014-4017.
    View publication on PubMed
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
1-dodecyl-1H-pyrrole-2,5-dione
-
 Homo sapiens
2,2'-[[(E)-1,2-diphenylethene-1,2-diyl]bis(benzene-4,1-diyloxy)]diethanesulfonate
-
 Homo sapiens
donepezil
-
 Homo sapiens
additional information the ensemble of compounds 1 and 2 can be used for the AChE activity assay and the inhibitor-screening by making use of the aggregation-induced emission feature of tetraphenyl ethylene compounds, method development, overview Homo sapiens
neostigmine
-
 Homo sapiens
tacrine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Homo sapiens
-
 acetate + choline
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain cortex
-
 Homo sapiens
-
hippocampus
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
 Homo sapiens acetate + choline
-
 ?
acetylthiocholine iodide + H2O
-
 Homo sapiens acetate + thiocholine iodide
-
 ?
additional information the ensemble of compound 1 and compound 2 can be used for the AChE activity assay and the inhibitor-screening by making use of the aggregation-induced emission feature of tetraphenyl ethylene compounds, method development, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000064
-
 pH 7.3 Homo sapiens donepezil
0.0000118
-
 pH 7.3 Homo sapiens tacrine
0.0000503
-
 pH 7.3 Homo sapiens neostigmine

General Information

General Information Comment Organism
malfunction Alzheimer's disease, a neurodegenerative disease characterized by a low concentration of acetylcholine in the hippocampus and cortex, is the leading cause of dementia among older people Homo sapiens
physiological function hydrolysis of acetylcholine by acetylcholinesterase is a key process for the regulation of the neutral response system Homo sapiens