Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Scopolamine | induces and increase of AChE activity in the cortex and hippocampus of mice | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-O-methylhonokiol | isolated from ethanol extract of Magnolia officinalis. 4-O-methylhonokiol also dose-dependently attenuates the scopolamine-induced increase of AChE activity in the cortex and hippocampus of mice | Mus musculus | |
additional information | inhibitory effect on AChE of the ethanol extract of Magnolia officinalis, overview | Mus musculus | |
tacrine | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | Mus musculus | - |
acetate + choline | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
male ICR mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain cortex | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylcholine + H2O | - |
Mus musculus | acetate + choline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000012 | - |
pH 7.4, 25°C | Mus musculus | 4-O-methylhonokiol | |
0.000135 | - |
pH 7.4, 25°C | Mus musculus | tacrine |