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Literature summary for 3.1.1.7 extracted from
- Inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds: Pig versus minipig acetylcholinesterase (2008), Toxicology, 244, 35-41.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cyclosarin | a nerve agent | Sus scrofa |  |
| additional information | reactivation of organophosphorous compound/nerve agent-inhibited AChE by antimuscarinic drug oximes obidoxime, pralidoxime and HI 6, overview, aging and spontaneous reactivation of inhibited AChE | Sus scrofa | |
| paraoxon | - |
Sus scrofa | |
| VR | nerve agent | Sus scrofa | |
| VX (nerve agent) | a nerve agent | Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Michaelis-Menten kinetics | Sus scrofa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
White Landrace pig and Goettingen minipig | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activity in White Landrace pig and Goettingen minipig whole blood and plasma, overview | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-acetylthiocholine iodide + H2O | detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB | Sus scrofa | acetate + thiocholine iodide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AChE | - |
Sus scrofa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Sus scrofa |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | inhibition kinetics of pesticides, pseudo-first-order rate constants, overview | Sus scrofa |
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