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Literature summary for 3.1.1.7 extracted from

  • Nawaz, S.A.; Umbreen, S.; Kahlid, A.; Ansari, F.L.; Choudhary, M.I.
    Structural insight into the inhibition of acetylcholinesterase by 2,3,4, 5-tetrahydro-1, 5-benzothiazepines (2008), J. Enzyme Inhib. Med. Chem., 23, 206-212.
    View publication on PubMed
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
2-(2-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl)phenol
-
 Tetronarce californica
2-[2-(4-fluorophenyl)-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol
-
 Tetronarce californica
2-[2-(4-methylphenyl)-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol
-
 Tetronarce californica
galanthamine
-
 Tetronarce californica
additional information three-dimensional structure and molecular docking to AChE of benzodiazepine inhibitors, amino acid residues involved in docking, overview Tetronarce californica

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics, overview Tetronarce californica

Organism

Organism UniProt Comment Textmining
Tetronarce californica P04058 type VI-S AChE
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
 Tetronarce californica acetate + thiocholine
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Tetronarce californica
type VI-S AChE
-
 Tetronarce californica

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Tetronarce californica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Tetronarce californica

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0008
-
 pH 8.0, 25°C Tetronarce californica 2-(2-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl)phenol
0.0011
-
 pH 8.0, 25°C Tetronarce californica 2-[2-(4-fluorophenyl)-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol
0.0015
-
 pH 8.0, 25°C Tetronarce californica 2-[2-(4-methylphenyl)-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol