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Literature summary for 3.1.1.7 extracted from

  • Weiner, L.; Shnyrov, V.L.; Konstantinovskii, L.; Roth, E.; Ashani, Y.; Silman, I.
    Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors (2009), Biochemistry, 48, 563-574.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
BW284c51 a reversible elongated gorge-spanning inhibitor, which bridges the two sites, the anionic subsite at the bottom of the active-site gorge and the peripheral anionic site at the entrance to the gorge Tetronarce californica
decamethonium a reversible elongated gorge-spanning inhibitor, which bridges the two sites, the anionic subsite at the bottom of the active-site gorge and the peripheral anionic site at the entrance to the gorge Tetronarce californica
edrophonium a reversible active-site directed inhibitor, which interacts with the catalytic anionic subsite, at the bottom of the active-site gorge Tetronarce californica
propidium a reversible peripheral anionic site inhibitor, which interacts with a site at the entrance to the gorge Tetronarce californica
tacrine a reversible active-site directed inhibitor, which interacts with the catalytic anionic subsite, at the bottom of the active-site gorge Tetronarce californica
tubocurarine a reversible peripheral anionic site inhibitor, which interacts with a site at the entrance to the gorge Tetronarce californica

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information the enzyme is glycosylphosphatidylinositol-anchored Tetronarce californica
-
-

Organism

Organism UniProt Comment Textmining
Tetronarce californica
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from electric organ by affinity chromatography Tetronarce californica

Source Tissue

Source Tissue Comment Organism Textmining
electric organ
-
Tetronarce californica
-

Subunits

Subunits Comment Organism
dimer
-
Tetronarce californica
More interaction between the two subdomains of the enzyme and ligands involved, overview Tetronarce californica

Synonyms

Synonyms Comment Organism
AChE
-
Tetronarce californica

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
23
-
assay at Tetronarce californica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Tetronarce californica

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics and thermodynamics, overview Tetronarce californica