Literature summary for 3.1.1.7 extracted from

Wang, Y.H.; Zhang, Z.K.; Yang, F.M.; Sun, Q.Y.; He, H.P.; Di, Y.T.; Mu, S.Z.; Lu, Y.; Chang, Y.; Zheng, Q.T.; Ding, M.; Dong, J.H.; Hao, X.J.
Benzylphenethylamine alkaloids from Hosta plantaginea with inhibitory activity against tobacco mosaic virus and acetylcholinesterase (2007), J. Nat. Prod., 70, 1458-1461.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(+)-haemanthamine	-	Homo sapiens
1-O-acetyllycorine	-	Homo sapiens
10-O-methylhostasine	a benzylphenethylamine alkaloid from Hosta plantaginea	Homo sapiens
11-hydroxygalantamine	-	Homo sapiens
7-deoxy-trans-dihydronarciclasine	-	Homo sapiens
8-demethoxy-10-O-methylhostasine	a benzylphenethylamine alkaloid from Hosta plantaginea	Homo sapiens
8-demethoxyhostasine	benzylphenethylamine alkaloid from Hosta plantaginea	Homo sapiens
9-O-demethyl-7-O-methyllycorenine	a benzylphenethylamine alkaloid from Hosta plantaginea	Homo sapiens
assoanine	-	Homo sapiens
epinorgalantamine	-	Homo sapiens
galantamine	-	Homo sapiens
hostasine	a benzylphenethylamine alkaloid from Hosta plantaginea	Homo sapiens
additional information	no inhibition by albomaculine, 7-deoxy-trans-dihydronarciclasine, and haemanthidine	Homo sapiens
norsanguinine	-	Homo sapiens
sanguinine	-	Homo sapiens
tacrine	-	Homo sapiens
ungeremine	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
AChE	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0001	-	-	Homo sapiens	sanguinine
0.00035	-	-	Homo sapiens	ungeremine
0.00096	-	-	Homo sapiens	1-O-acetyllycorine
0.00107	-	-	Homo sapiens	galantamine
0.00143	-	-	Homo sapiens	norsanguinine
0.00161	-	-	Homo sapiens	11-hydroxygalantamine
0.0018	-	-	Homo sapiens	7-deoxy-trans-dihydronarciclasine
0.0023	-	-	Homo sapiens	8-demethoxy-10-O-methylhostasine
0.00387	-	-	Homo sapiens	assoanine
0.009	-	-	Homo sapiens	epinorgalantamine
0.452	-	-	Homo sapiens	(+)-haemanthamine

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Release 2023.1 (January 2023)