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Literature summary for 3.1.1.7 extracted from

  • Gadepalli, R.S.; Rimoldi, J.M.; Fronczek, F.R.; Nillos, M.; Gan, J.; Deng, X.; Rodriguez-Fuentes, G.; Schlenk, D.
    Synthesis of fenthion sulfoxide and fenoxon sulfoxide enantiomers: effect of sulfur chirality on acetylcholinesterase activity (2007), Chem. Res. Toxicol., 20, 257-262.
    View publication on PubMed
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
(R)-(+)-fenoxon sulfoxide
-
 Electrophorus electricus
(R)-(+)-fenoxon sulfoxide
-
 Homo sapiens
(R)-(+)-fenthion sulfoxide
-
 Electrophorus electricus
(R)-(+)-fenthion sulfoxide
-
 Homo sapiens
(rac) fenoxon sulfoxide
-
 Electrophorus electricus
(rac) fenoxon sulfoxide
-
 Homo sapiens
(rac) fenthion sulfoxide
-
 Electrophorus electricus
(rac) fenthion sulfoxide
-
 Homo sapiens
(S)-(-)-fenoxon sulfoxide
-
 Electrophorus electricus
(S)-(-)-fenoxon sulfoxide
-
 Homo sapiens
(S)-(-)-fenthion sulfoxide
-
 Electrophorus electricus
(S)-(-)-fenthion sulfoxide
-
 Homo sapiens
fenoxon
-
 Electrophorus electricus
fenoxon
-
 Homo sapiens
fenthion
-
 Electrophorus electricus
fenthion
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Electrophorus electricus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation lyophilized recombinant enzyme Homo sapiens
-
commercial preparation lyophilized recombinant enzyme Electrophorus electricus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
 Homo sapiens thiocholine + acetate
-
 ?
acetylthiocholine + H2O
-
 Electrophorus electricus thiocholine + acetate
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Homo sapiens
AChE
-
 Electrophorus electricus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens
25
-
 assay at Electrophorus electricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens
7.5
-
 assay at Electrophorus electricus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0012
-
 (R)-(+)-fenoxon sulfoxide pH 7.5, 25°C, recombinant enzyme Homo sapiens
0.0013
-
 (R)-(+)-fenoxon sulfoxide pH 7.5, 25°C, recombinant enzyme Electrophorus electricus
0.0017
-
 fenoxon pH 7.5, 25°C, recombinant enzyme Homo sapiens
0.0017
-
 (rac) fenoxon sulfoxide pH 7.5, 25°C, recombinant enzyme Electrophorus electricus
0.0041
-
 fenoxon pH 7.5, 25°C, recombinant enzyme Electrophorus electricus
0.0043
-
 (rac) fenoxon sulfoxide pH 7.5, 25°C, recombinant enzyme Homo sapiens
0.0143
-
 fenthion pH 7.5, 25°C, recombinant enzyme Homo sapiens
0.0215
-
 (S)-(-)-fenoxon sulfoxide pH 7.5, 25°C, recombinant enzyme Electrophorus electricus
0.0221
-
 fenthion pH 7.5, 25°C, recombinant enzyme Electrophorus electricus
0.0407
-
 (S)-(-)-fenoxon sulfoxide pH 7.5, 25°C, recombinant enzyme Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0065
-
 pH 7.5, 25°C, recombinant enzyme Electrophorus electricus (R)-(+)-fenoxon sulfoxide
0.0069
-
 pH 7.5, 25°C, recombinant enzyme Homo sapiens (R)-(+)-fenoxon sulfoxide
0.0087
-
 pH 7.5, 25°C, recombinant enzyme Electrophorus electricus (rac) fenoxon sulfoxide
0.0097
-
 pH 7.5, 25°C, recombinant enzyme Homo sapiens fenoxon
0.021
-
 pH 7.5, 25°C, recombinant enzyme Electrophorus electricus fenoxon
0.023
-
 pH 7.5, 25°C, recombinant enzyme Homo sapiens (rac) fenoxon sulfoxide
0.0807
-
 pH 7.5, 25°C, recombinant enzyme Homo sapiens fenthion
0.111
-
 pH 7.5, 25°C, recombinant enzyme Electrophorus electricus (S)-(-)-fenoxon sulfoxide
0.114
-
 pH 7.5, 25°C, recombinant enzyme Electrophorus electricus fenthion
0.23
-
 pH 7.5, 25°C, recombinant enzyme Homo sapiens (S)-(-)-fenoxon sulfoxide
1
-
 above, pH 7.5, 25°C, recombinant enzyme Homo sapiens (rac) fenthion sulfoxide
1
-
 above, pH 7.5, 25°C, recombinant enzyme Electrophorus electricus (rac) fenthion sulfoxide
1
-
 above, pH 7.5, 25°C, recombinant enzyme Homo sapiens (R)-(+)-fenthion sulfoxide
1
-
 above, pH 7.5, 25°C, recombinant enzyme Electrophorus electricus (R)-(+)-fenthion sulfoxide
1
-
 above, pH 7.5, 25°C, recombinant enzyme Homo sapiens (S)-(+)-fenthion sulfoxide
1
-
 above, pH 7.5, 25°C, recombinant enzyme Electrophorus electricus (S)-(+)-fenthion sulfoxide