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Literature summary for 3.1.1.7 extracted from

  • Mazzanti, C.M.; Spanevello, R.M.; Obregon, A.; Pereira, L.B.; Streher, C.A.; Ahmed, M.; Mazzanti, A.; Graca, D.L.; Morsch, V.M.; Schetinger, M.R.
    Ethidium bromide inhibits rat brain acetylcholinesterase activity in vitro (2006), Chem. Biol. Interact., 162, 121-127.
    View publication on PubMed
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
Ethidium bromide uncompetitive inhibition at concentrations of 0.00625-0.1 mM in all brain regions except for the cerebellum where the inhibition is of a mixed-type Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
cerebellum
-
 Rattus norvegicus
-
cerebral cortex
-
 Rattus norvegicus
-
hippocampus
-
 Rattus norvegicus
-
striatum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
 Rattus norvegicus thiocholine + acetate
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information tissue-dependent inhibition kinetics, overview Rattus norvegicus
0.0024 0.0059 Ethidium bromide pH 7.5, 25°C Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0049 0.009 pH 7.5, 25°C Rattus norvegicus Ethidium bromide