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Literature summary for 3.1.1.7 extracted from

  • Piazzi, L.; Belluti, F.; Bisi, A.; Gobbi, S.; Rizzo, S.; Bartolini, M.; Andrisano, V.; Recanatini, M.; Rampa, A.
    Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones (2007), Bioorg. Med. Chem., 15, 575-585.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-[10-(benzylmethylamino)decyloxy]xanthen-9-one
-
Homo sapiens
3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one
-
Homo sapiens
3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one
-
Homo sapiens
3-[3-(benzylmethylamino)propoxy]xanthen-9-one
-
Homo sapiens
3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one
-
Homo sapiens
3-[4-(benzylmethylamino)butoxy]xanthen-9-one
-
Homo sapiens
3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one
-
Homo sapiens
3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one
-
Homo sapiens
3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one
-
Homo sapiens
3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one
-
Homo sapiens
3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
-
Homo sapiens
3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
-
Homo sapiens
3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
Homo sapiens
3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
Homo sapiens
3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
Homo sapiens
3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
Homo sapiens
3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
Homo sapiens
3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
Homo sapiens
3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one
-
Homo sapiens
3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one
-
Homo sapiens
3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one
-
Homo sapiens
3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one
-
Homo sapiens
3-[8-(benzylmethylamino)octyloxy]xanthen-9-one
-
Homo sapiens
3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one
-
Homo sapiens
3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones structure-activity relationships, overview Homo sapiens
6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one
-
Homo sapiens
xanthostigmine
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation from erythrocytes Homo sapiens
-
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine iodide + H2O
-
Homo sapiens thiocholine iodide + acetate
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0003
-
-
Homo sapiens xanthostigmine
0.00218
-
pH 8.0, 37°C Homo sapiens 3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
0.00232
-
pH 8.0, 37°C Homo sapiens 6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one
0.00268
-
pH 8.0, 37°C Homo sapiens 3-[3-(benzylmethylamino)propoxy]xanthen-9-one
0.00282
-
pH 8.0, 37°C Homo sapiens 3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one
0.00289
-
pH 8.0, 37°C Homo sapiens 3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one
0.00315
-
pH 8.0, 37°C Homo sapiens 3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one
0.0034
-
pH 8.0, 37°C Homo sapiens 3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one
0.00625
-
pH 8.0, 37°C Homo sapiens 3-[4-(benzylmethylamino)butoxy]xanthen-9-one
0.00778
-
pH 8.0, 37°C Homo sapiens 3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one
0.00784
-
pH 8.0, 37°C Homo sapiens 3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one
0.0103
-
pH 8.0, 37°C Homo sapiens 3-[8-(benzylmethylamino)octyloxy]xanthen-9-one
0.04
-
pH 8.0, 37°C Homo sapiens 3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
0.127
-
pH 8.0, 37°C Homo sapiens 3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
0.138
-
pH 8.0, 37°C Homo sapiens 3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
0.152
-
pH 8.0, 37°C Homo sapiens 3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one
0.155
-
pH 8.0, 37°C Homo sapiens 3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one
0.36
-
pH 8.0, 37°C Homo sapiens 3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
0.388
-
pH 8.0, 37°C Homo sapiens 3-[10-(benzylmethylamino)decyloxy]xanthen-9-one
0.413
-
pH 8.0, 37°C Homo sapiens 3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one
0.433
-
pH 8.0, 37°C Homo sapiens 3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
0.565
-
pH 8.0, 37°C Homo sapiens 3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one
0.594
-
pH 8.0, 37°C Homo sapiens 3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
0.626
-
pH 8.0, 37°C Homo sapiens 3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one
0.908
-
pH 8.0, 37°C Homo sapiens 3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one
1.05
-
pH 8.0, 37°C Homo sapiens 3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one