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Literature summary for 3.1.1.7 extracted from

  • Eckert, S.; Eyer, P.; Mueckter, H.; Worek, F.
    Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds (2006), Biochem. Pharmacol., 72, 344-357.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
huperzine A reversible inhibition, effects of pre-inhibition by physostigmine, pyridostigmine and huperzine A on inhibition by paraoxon, overview Homo sapiens
paraoxon irreversible inhibition, effects of pre-inhibition by physostigmine, pyridostigmine and huperzine A on inhibition by paraoxon, overview Homo sapiens
physostigmine reversible inhibition, effects of pre-inhibition by physostigmine, pyridostigmine and huperzine A on inhibition by paraoxon, overview Homo sapiens
pyridostigmine reversible inhibition, effects of pre-inhibition by physostigmine, pyridostigmine and huperzine A on inhibition by paraoxon, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine iodide + H2O
-
Homo sapiens thiocholine + acetate
-
?

Synonyms

Synonyms Comment Organism
AChE
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information steady-state inhibition kinetics, overview Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00004
-
pH 7.4, 37°C Homo sapiens huperzine A
0.000061
-
pH 7.4, 37°C Homo sapiens physostigmine
0.000904
-
pH 7.4, 37°C Homo sapiens pyridostigmine