Literature summary for 3.1.1.7 extracted from

Cometa, M.F.; Lorenzini, P.; Fortuna, S.; Volpe, M.T.; Meneguz, A.; Palmery, M.
In vitro inhibitory effect of aflatoxin B1 on acetylcholinesterase activity in mouse brain (2005), Toxicology, 206, 125-135.

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Inhibitors

Inhibitors	Comment	Organism	Structure
aflatoxin B1	50% inhibition at 0.031 mM by increase of Km-value and decrease of vmax-value. Partial recativation by 2-aldoxime, i.e. 2-PAM, pyridin-2-aldoxime 1-methoiodide	Mus musculus
BW284c51	50% inhibition at 0.000021 mM	Mus musculus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.04	-	acetylthiocholine	pH 7.2, 25°C	Mus musculus
0.062	-	acetylthiocholine	pH 7.2, 25°C, presence of aflatoxin B1 at 0.001 mM	Mus musculus
0.133	-	acetylthiocholine	pH 7.2, 25°C, presence of aflatoxin B1 at 0.1 mM	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isoforms G1 and G4	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetylthiocholine + H2O	-	Mus musculus	acetate + thiocholine	-	?

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Release 2023.1 (January 2023)