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Literature summary for 3.1.1.7 extracted from

  • Ma, E.B.; He, Y.P.; Zhu, K.Y.
    Comparative studies of acetylcholinesterases purified from two field populations of the oriental migratory locust (Locusta migratoria manilensis): implications of insecticide resistance (2004), Pestic. Biochem. Physiol., 78, 67-77.
No PubMed abstract available
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
BW284c51 0.001 mM, almost complete inhibition Locusta migratoria manilensis
chlorpyrifos oxon enzyme from Huanghua population is 62fold less sensitive than from Pingshan population Locusta migratoria manilensis
demeton-S-methyl enzyme from Huanghua population is 2fold less sensitive than from Pingshan population Locusta migratoria manilensis
eserine 0.001 mM, almost complete inhibition Locusta migratoria manilensis
ethopropazine about 5% inhibition at 0.001 mM Locusta migratoria manilensis
paraoxon enzyme from Huanghua population is 1.6fold less sensitive than from Pingshan population Locusta migratoria manilensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
 butyrylthiocholine pH 7.5, 24°C, Huanghua population Locusta migratoria manilensis
0.026
-
 butyrylthiocholine pH 7.5, 24°C, Pingshan population Locusta migratoria manilensis
0.043
-
 acetylthiocholine pH 7.5, 24°C, Pingshan population Locusta migratoria manilensis
0.044
-
 acetylthiocholine pH 7.5, 24°C, Huanghua population Locusta migratoria manilensis

Organism

Organism UniProt Comment Textmining
Locusta migratoria manilensis
-
 collected from Huanghua and Pingshan County
-

Purification (Commentary)

Purification (Comment) Organism
purification factor and yield are significantly lower in Huanghua population than in Pingshan population Locusta migratoria manilensis

Source Tissue

Source Tissue Comment Organism Textmining
abdomen
-
 Locusta migratoria manilensis
-
femur
-
 Locusta migratoria manilensis
-
head
-
 Locusta migratoria manilensis
-
thorax
-
 Locusta migratoria manilensis
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00066
-
 24°C, pH 7.5, Pingshan population, female, thorax Locusta migratoria manilensis
0.00078
-
 24°C, pH 7.5, Pingshan population, female, abdomen Locusta migratoria manilensis
0.00082
-
 24°C, pH 7.5, Pingshan population, female, femur Locusta migratoria manilensis
0.00104
-
 24°C, pH 7.5, Pingshan population, male, abdomen Locusta migratoria manilensis
0.0011
-
 24°C, pH 7.5, Pingshan population, male, thorax Locusta migratoria manilensis
0.00122
-
 24°C, pH 7.5, Pingshan population, male, femur Locusta migratoria manilensis
0.0022
-
 24°C, pH 7.5, Pingshan population, female, head Locusta migratoria manilensis
0.0038
-
 24°C, pH 7.5, Pingshan population, male, head Locusta migratoria manilensis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
 Locusta migratoria manilensis thiocholine + acetate
-
 ?
butyrylthiocholine + H2O
-
 Locusta migratoria manilensis thiocholine + butanoate
-
 ?