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Literature summary for 3.1.1.7 extracted from

  • Ranaei-Siadat, S.O.; Riazi, G.H.; Sadeghi, M.; Chang, L.S.; Lin, S.R.; Eghtesadi-Araghi, P.; Hakimelahi, G.H.; Moosavi-Movahedi, A.A.
    Modification of substrate inhibition of synaptosomal acetylcholinesterase by cardiotoxins (2004), J. Biochem. Mol. Biol., 37, 330-338.
    View publication on PubMed
Search for more literature for 3.1.1.7

Activating Compound

Activating Compound Comment Organism Structure
cardiotoxin I activation by modification of substrate inhibition, attachment to loop II to peripheral site of enzyme and stabilization of functional conformation Ovis aries
cardiotoxin II activation by modification of substrate inhibition, attachment to loop II to peripheral site of enzyme and stabilization of functional conformation Ovis aries
cardiotoxin III activation by modification of substrate inhibition, attachment to loop II to peripheral site of enzyme and stabilization of functional conformation Ovis aries
cardiotoxin n activation by modification of substrate inhibition, attachment to loop II to peripheral site of enzyme and stabilization of functional conformation Ovis aries
cardiotoxin V activation by modification of substrate inhibition, attachment to loop II to peripheral site of enzyme and stabilization of functional conformation Ovis aries
additional information in presence of cardiotoxin IV, substrate inhibition persists Ovis aries

Inhibitors

Inhibitors Comment Organism Structure
acetylthiocholine
-
 Ovis aries

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.082
-
 acetylthiocholine pH 7.4 Ovis aries
0.106
-
 acetylthiocholine pH 7.4, presence of cardiotoxin V Ovis aries
0.124
-
 acetylthiocholine pH 7.4, presence of cardiotoxin I Ovis aries
0.139
-
 acetylthiocholine pH 7.4, presence of cardiotoxin n Ovis aries
0.14
-
 acetylthiocholine pH 7.4, presence of cardiotoxin II Ovis aries
0.144
-
 acetylthiocholine pH 7.4, presence of cardiotoxin III Ovis aries
0.181
-
 acetylthiocholine pH 7.4, presence of cardiotoxin IV Ovis aries

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex Ovis aries
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
 Ovis aries thiocholine + acetate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.84
-
 acetylthiocholine pH 7.4 Ovis aries