Literature summary for 3.1.1.7 extracted from

Carageorgiou, H.; Tzotzes, V.; Sideris, A.; Zarros, A.; Tsakiris, S.
Cadmium effects on brain acetylcholinesterase activity and antioxidant status of adult rats: modulation by zinc, calcium and L-cysteine co-administration (2005), Basic Clin. Pharmacol. Toxicol., 97, 320-324.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Ca2+	intraperitoneal administration of 1 mg/kg/day for 14 days, increase in enzyme activity by 53%, no change of total antioxidant status	Rattus norvegicus
Cd2+	intraperitoneal administration of 1 mg/kg/day for 14 days, increase in enzyme activity by 46% and decrease of total antioxidant status	Rattus norvegicus
L-cysteine	intraperitoneal administration of 7 mg/kg/day for 14 days, increase in enzyme activity by 185% and increase of total antioxidant status. L-cysteine given before a toxic dose of cadmium results in increase of enzyme activity up to 85%, a total antioxidant status similar to the control values, and survival of the treated animals	Rattus norvegicus
Zn2+	intraperitoneal administration of 1 mg/kg/day for 14 days, increase in enzyme activity by 18%, no change of total antioxidant status	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)