Literature summary for 3.1.1.7 extracted from

Kardos, S.A.; Sultatos, L.G.
Interactions of the organophosphates paraoxon and methyl paraoxon with mouse brain acetylcholinesterase (2000), Toxicol. Sci., 58, 118-126.

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Inhibitors

Inhibitors	Comment	Organism	Structure
methyl paraoxon	reversible binding to a site on acetylcholinesterase distinct from the active site reduces their subsequent capacity to phosphorylate the active site, probably by steric hindrance or allosteric modification of the active site	Mus musculus
paraoxon	26% inhibition at 0.0000001 mM, reversible binding to a site on acetylcholinesterase distinct from the active site reduces their subsequent capacity to phosphorylate the active site	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetylcholine iodide + H2O	-	Mus musculus	acetate + choline iodide	-	?

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Release 2023.1 (January 2023)