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Literature summary for 3.1.1.7 extracted from

  • Boublik, Y.; Saint-Aguet, P.; Lougarre, A.; Arnaud, M.; Villatte, F.; Estrada-Mondaca, S.; Fournier, D.
    Acetylcholinesterase engineering for detection of insecticide residues (2002), Protein Eng., 15, 43-50.
    View publication on PubMed
Search for more literature for 3.1.1.7

Cloned(Commentary)

Cloned (Comment) Organism
expressed in baculovirus Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
D375G increased sensitivity for malaoxon, omethoate and paraoxon Drosophila melanogaster
E69W increased sensitivity for carbaryl, malaoxon, omethoate and paraoxon Drosophila melanogaster
E69Y increased sensitivity for carbaryl, malaoxon, omethoate and paraoxon Drosophila melanogaster
F330I increased sensitivity for malaoxon, omethoate and paraoxon Drosophila melanogaster
F330L increased sensitivity for malaoxon, omethoate and paraoxon Drosophila melanogaster
L328F increased sensitivity for omethoate and paraoxon Drosophila melanogaster
R70V increased sensitivity for carbaryl and omethoate Drosophila melanogaster
V318D increased sensitivity for carbaryl, malaoxon and paraoxon Drosophila melanogaster
W321L increased sensitivity for carbaryl, malaoxon, omethoate and paraoxon Drosophila melanogaster
Y370A increased sensitivity for carbaryl, malaoxon, omethoate and paraoxon Drosophila melanogaster
Y370F increased sensitivity for carbaryl, malaoxon, omethoate and paraoxon Drosophila melanogaster
Y374A increased sensitivity for carbaryl, malaoxon and paraoxon Drosophila melanogaster
Y71D increased sensitivity for carbaryl, malaoxon, omethoate and paraoxon Drosophila melanogaster
Y73Q increased sensitivity for carbaryl, malaoxon, omethoate and paraoxon Drosophila melanogaster

Inhibitors

Inhibitors Comment Organism Structure
Carbaryl
-
 Drosophila melanogaster
malaoxon
-
 Drosophila melanogaster
omethoate
-
 Drosophila melanogaster
paraoxon
-
 Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
-
 Drosophila melanogaster thiocholine + acetate
-
 ?