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Literature summary for 3.1.1.7 extracted from

  • Shi, J.; Tai, K.; McCammon, J.A.; Taylor, P.; Johnson, D.A.
    Nanosecond dynamics of the mouse acetylcholinesterase Cys69-Cys96 omega loop (2003), J. Biol. Chem., 278, 30905-30911.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Mus musculus

Protein Variants

Protein Variants Comment Organism
E81C reporter group 5-((((2-acetyl)amino)ethyl)amino)naphthalene-1-sulfonic acid attached to cysteine Mus musculus
E84C reporter group 5-((((2-acetyl)amino)ethyl)amino)naphthalene-1-sulfonic acid attached to cysteine Mus musculus
L76C reporter group 5-((((2-acetyl)amino)ethyl)amino)naphthalene-1-sulfonic acid attached to cysteine Mus musculus
Y124C reporter group 5-((((2-acetyl)amino)ethyl)amino)naphthalene-1-sulfonic acid attached to cysteine Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
fasciculin binds at the mouth of the gorge, decreases the mobility of reporter groups attached to L76C and Y124C, increases the mobility of reporter groups attached to E81C and E84C Mus musculus
huperzine binds at the base of the active site gorge, has no effect on the mobility of reporter groups attached to L76C and Y124C, increases the mobility of reporter groups attached to E81C and E84C Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P21836
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine iodide + H2O
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Mus musculus thiocholine iodide + acetate
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