Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
F295L/F297I/Y337A | mutant enzyme can be partially reactivated after phosphonylation | Mus musculus |
F295L/Y337A | mutant enzyme can be partially reactivated after phosphonylation | Mus musculus |
F297I/Y337A | mutant enzyme can be partially reactivated after phosphonylation | Mus musculus |
Y337A | reactivation of mutant enzyme after phosphonylation with RP-3,3-dimethylbutyl methylphosphonyl thiocholine with 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide is better than reactivation of wild-type enzyme | Mus musculus |
Y337A/F338A | mutant enzyme can be partially reactivated after phosphonylation | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
RP cycloheptyl methylphosphonyl thiocholine | phosphonylates the enzyme, wild-type enzyme and mutant enzymes can only poorly be reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide | Mus musculus | |
RP-3,3-dimethylbutyl methylphosphonyl thiocholine | phosphonylates the enzyme, wild-type enzyme and mutant enzymes can only poorly be reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide | Mus musculus | |
RP-isopropyl methylphosphonyl thiocholine | phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide | Mus musculus | |
SP-3,3-dimethylbutyl methylphosphonyl thiocholine | phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide | Mus musculus | |
SP-cycloheptyl methylphosphonyl thiocholine | phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide | Mus musculus | |
SP-isopropyl methylphosphonyl thiocholine | phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylthiocholine + H2O | - |
Mus musculus | thiocholine + acetate | - |
? |