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Literature summary for 3.1.1.7 extracted from

  • Kovarik, Z.; Radic, Z.; Berman, H.A.; Simeon-Rudolf, V.; Reiner, E.; Taylor, P.
    Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates (2004), Biochemistry, 43, 3222-3229.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
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Mus musculus

Protein Variants

Protein Variants Comment Organism
F295L/F297I/Y337A mutant enzyme can be partially reactivated after phosphonylation Mus musculus
F295L/Y337A mutant enzyme can be partially reactivated after phosphonylation Mus musculus
F297I/Y337A mutant enzyme can be partially reactivated after phosphonylation Mus musculus
Y337A reactivation of mutant enzyme after phosphonylation with RP-3,3-dimethylbutyl methylphosphonyl thiocholine with 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide is better than reactivation of wild-type enzyme Mus musculus
Y337A/F338A mutant enzyme can be partially reactivated after phosphonylation Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
RP cycloheptyl methylphosphonyl thiocholine phosphonylates the enzyme, wild-type enzyme and mutant enzymes can only poorly be reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide Mus musculus
RP-3,3-dimethylbutyl methylphosphonyl thiocholine phosphonylates the enzyme, wild-type enzyme and mutant enzymes can only poorly be reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide Mus musculus
RP-isopropyl methylphosphonyl thiocholine phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide Mus musculus
SP-3,3-dimethylbutyl methylphosphonyl thiocholine phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide Mus musculus
SP-cycloheptyl methylphosphonyl thiocholine phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide Mus musculus
SP-isopropyl methylphosphonyl thiocholine phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylthiocholine + H2O
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Mus musculus thiocholine + acetate
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