Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.1.7 extracted from

  • Johnson, J.L.; Cusack, B.; Davies, M.P.; Fauq, A.; Rosenberry, T.L.
    Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate (2003), Biochemistry, 42, 5438-5452.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
acetylthiocholine substrate activiation below 1 mM is only seen in W86F mutant but not in wild-type or D74G mutant Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Protein Variants

Protein Variants Comment Organism
D74G shows no substrate activation Homo sapiens
W86F shows substrate activation at low concentration and substrate inhibition at high concentrations Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
acetylthiocholine substrate inhibition above 1 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.047
-
3-(acetamido)-N,N,N-trimethylanilinum pH 8 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
W86F and D74G mutant Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
acetylcholine + H2O = choline + acetate mechanism Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-(acetamido)-N,N,N-trimethylanilinum + H2O ATMA Homo sapiens ?
-
?
acetylthiocholine + H2O
-
Homo sapiens thiocholine + acetate
-
?