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Literature summary for 3.1.1.67 extracted from
- Purification and characterization of human heart fatty acid ethyl ester synthase/carboxylesterase (1996), J. Mol. Cell. Cardiol., 28, 2027-2032.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | - |
oleate | enzyme with FAEES/carboxylesterase activity from heart | Homo sapiens |  |
| 300 | - |
ethanol | enzyme with FAEES/carboxylesterase activity from heart | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | enzyme with FAEES/carboxylesterase activity from heart | Homo sapiens | 5829 | - |
| microsome | enzyme with FAEES/carboxylesterase activity from heart | Homo sapiens | - |
- |
| mitochondrion | enzyme with FAEES/carboxylesterase activity from heart | Homo sapiens | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 62000 | - |
x * 62000, enzyme with FAEES/carboxylesterase activity from heart, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fatty acid + ethanol | Homo sapiens | FAEES matabolizes ethanol nonoxidatively in those extrahepatic organs most commonly damaged by alcohol abuse, enzyme may play an important role in alcohol-induced cardiomyopathy | fatty acyl ethyl ester + H2O | product has potentially toxic effects | ? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 9000fold | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | enzyme with FAEES/carboxylesterase activity, structurally different from synthase I-III | Homo sapiens | - |
| heart | ventricular myocardium | Homo sapiens | - |
| myocardium | ventricular | Homo sapiens | - |
| myocardium | enzyme with FAEES/carboxylesterase activity, structurally different from synthase I-III | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fatty acid + ethanol | - |
Homo sapiens | fatty acyl ethyl ester + H2O | - |
? | |
| fatty acid + ethanol | FAEES matabolizes ethanol nonoxidatively in those extrahepatic organs most commonly damaged by alcohol abuse, enzyme may play an important role in alcohol-induced cardiomyopathy | Homo sapiens | fatty acyl ethyl ester + H2O | product has potentially toxic effects | ? | |
| additional information | enzyme forms: enzyme with FAEES and carboxylesterase activity from heart, structurally different from synthase I and III with GST activity and from synthase II without GST activity | Homo sapiens | ? | - |
? | |
| oleate + ethanol | - |
Homo sapiens | ethyl oleate + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 62000, enzyme with FAEES/carboxylesterase activity from heart, SDS-PAGE | Homo sapiens |
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Release 2023.1 (January 2023)
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