Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | liver, at the lumenal side | Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
fatty acid + ethanol | Homo sapiens | - |
fatty acyl ethyl ester + H2O | responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | low activity | Homo sapiens | - |
duodenum | mucosa, low activity | Homo sapiens | - |
gall bladder | - |
Homo sapiens | - |
gastric mucosa | ventricular, low activity | Homo sapiens | - |
heart | low activity | Homo sapiens | - |
liver | highest activity in liver, followed by pancreas | Homo sapiens | - |
lung | - |
Homo sapiens | - |
additional information | not in serum | Homo sapiens | - |
pancreas | highest activity in liver, followed by pancreas | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.0028 | - |
pH 7.4, 37°C, liver microsomes | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fatty acid + ethanol | - |
Homo sapiens | fatty acyl ethyl ester + H2O | - |
? | |
fatty acid + ethanol | - |
Homo sapiens | fatty acyl ethyl ester + H2O | responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage | ? | |
additional information | FAEE synthase and carboxylesterase activities in liver and pancreas are possibly due to the same protein, that is, carboxylesterase ES-10, which is responsible for the hydrolysis of ethyl palmitate in liver microsomes | Homo sapiens | ? | - |
? | |
palmitate + ethanol | synthesis of ethyl palmitate is maximal at 0.2-0.4 mM palmitate | Homo sapiens | ethyl palmitate + H2O | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |