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Literature summary for 3.1.1.67 extracted from

  • Diczfalusy, M.A.; Björkhem, I.; Einarsson, C.; Hillebrant, C.G.; Alexson, S.E.H.
    Characterization of enzymes involved in formation of ethyl esters of long-chain fatty acids in humans (2001), J. Lipid Res., 42, 1025-1032.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome liver, at the lumenal side Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fatty acid + ethanol Homo sapiens
-
fatty acyl ethyl ester + H2O responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue low activity Homo sapiens
-
duodenum mucosa, low activity Homo sapiens
-
gall bladder
-
Homo sapiens
-
gastric mucosa ventricular, low activity Homo sapiens
-
heart low activity Homo sapiens
-
liver highest activity in liver, followed by pancreas Homo sapiens
-
lung
-
Homo sapiens
-
additional information not in serum Homo sapiens
-
pancreas highest activity in liver, followed by pancreas Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0028
-
pH 7.4, 37°C, liver microsomes Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fatty acid + ethanol
-
Homo sapiens fatty acyl ethyl ester + H2O
-
?
fatty acid + ethanol
-
Homo sapiens fatty acyl ethyl ester + H2O responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage ?
additional information FAEE synthase and carboxylesterase activities in liver and pancreas are possibly due to the same protein, that is, carboxylesterase ES-10, which is responsible for the hydrolysis of ethyl palmitate in liver microsomes Homo sapiens ?
-
?
palmitate + ethanol synthesis of ethyl palmitate is maximal at 0.2-0.4 mM palmitate Homo sapiens ethyl palmitate + H2O
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens