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Literature summary for 3.1.1.67 extracted from
- Fatty acid ethyl ester synthase, an enzyme for nonoxidative ethanol metabolism, is present in serum after liver and pancreatic injury (1996), Clin. Chem., 42, 24-27.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enzyme is responsible for the formation of fatty acid ethyl esters, which are mediators of ethanol-induced organ damage | Homo sapiens |
| medicine | patients with liver or pancreatic disease release FAEE synthase into their plasma | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | both cytosolic and membrane-bound | Homo sapiens | 5829 | - |
| membrane | both cytosolic and membrane-bound | Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| fatty acid + ethanol | Homo sapiens | patients with liver or pancreatic disease release FAEE synthase into their plasma permitting nonoxidative ethanol metabolism in the plasma | fatty acyl ethyl ester + H2O | responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage | ? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | substantially lower activity in erythrocytes than in leukocytes | Homo sapiens | - |
| leukocyte | substantially lower activity in erythrocytes than in leukocytes | Homo sapiens | - |
| liver | highest activity in liver and pancreas | Homo sapiens | - |
| pancreas | highest activity in liver and pancreas | Homo sapiens | - |
| plasma | low activity in normal plasma samples, patients with liver or pancreatic disease release FAEE synthase into their plasma | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| arachidonate + ethanol | - |
Homo sapiens | ethyl arachidonate + H2O | - |
? | |
| fatty acid + ethanol | - |
Homo sapiens | fatty acyl ethyl ester + H2O | - |
? | |
| fatty acid + ethanol | patients with liver or pancreatic disease release FAEE synthase into their plasma permitting nonoxidative ethanol metabolism in the plasma | Homo sapiens | fatty acyl ethyl ester + H2O | responsible for the formation of FAEE, which are mediators of ethanol-induced organ damage | ? | |
| oleate + ethanol | - |
Homo sapiens | ethyl oleate + H2O | - |
? | |
| palmitate + ethanol | - |
Homo sapiens | ethyl palmitate + H2O | - |
? | |
| stearate + ethanol | - |
Homo sapiens | ethyl stearate + H2O | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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