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Literature summary for 3.1.1.64 extracted from

  • Sheridan, C.; Boyer, N.P.; Crouch, R.K.; Koutalos, Y.
    RPE65 and the accumulation of retinyl esters in mouse retinal pigment epithelium (2017), Photochem. Photobiol., 93, 844-848 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus Q91ZQ5
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Source Tissue

Source Tissue Comment Organism Textmining

General Information

General Information Comment Organism
physiological function large amounts of esters accumulate in Rpe65-/- mice. Retinyl ester levels in Sv/129 wild type mice that are dark adapted for various intervals are similar to those in mice raised in cyclic light. In C57BL/6 mice, which contain less Rpe65 protein, dark adaptation is accompanied by an increase in ester levels compared to cyclic light controls. Retinyl ester levels are much higher in Rpe65-/- mice compared to wild type and keep increasing with age Mus musculus