Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the lipid membrane structure is critical for RPE65 enzymatic activity | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method, using 100 mM MES, pH 6.0, 30% (w/v) polyethylene glycol 200, and 2 mM dithiothreitol, at 22°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | microsome | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
retinal pigment epithelium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
all-trans-retinyl ester + H2O | - |
Homo sapiens | 11-cis-retinol + a fatty acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Rpe65 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | RPE65 operates in a multiprotein complex with retinol dehydrogenase 5 and retinal G protein-coupled receptor in RPE microsomes | Homo sapiens |