Literature summary for 3.1.1.61 extracted from

Saxl, R.L.; Anand, G.S.; Stock, A.M.
Synthesis and Biochemical Characterization of a Phosphorylated Analogue of the Response Regulator CheB (2001), Biochemistry, 40, 12896-12903.

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Protein Variants

Protein Variants	Comment	Organism
C207S/C309S	wild-type and mutant enzyme show significantly greater activity than the unphosphorylated proteins	Salmonella enterica subsp. enterica serovar Typhimurium
D56C/C207S/C309S	the half-life of mutant-SPO3 is 28 days, the unphosphorylated wild-type and mutant enzyme show the same enzyme activities	Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism	UniProt	Comment	Textmining
Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	enzyme is activated in vivo by phosphorylation of a single aspartate, Asp56, in its regulatory domain	Salmonella enterica subsp. enterica serovar Typhimurium

Reaction

Reaction	Comment	Organism	Reaction ID
protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol	the enzyme is a response regulator protein in the bacterial chemotaxis two-component signal transduction pathway	Salmonella enterica subsp. enterica serovar Typhimurium	a

Subunits

Subunits	Comment	Organism
More	the CheB protein is composed of at least 2 structurally distinct proportions: a C-terminal catalytic domain, and a N-terminal region which modulates esterase activity	Salmonella enterica subsp. enterica serovar Typhimurium

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Release 2023.1 (January 2023)