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Literature summary for 3.1.1.59 extracted from
- The juvenile hormone (JH) epoxide hydrolase gene in the honey bee (Apis mellifera) genome encodes a protein which has negligible participation in JH degradation (2010), J. Insect Physiol., 56, 1139-1146.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-octylthio-1,1,1-trifluoro-2-propanone | specific inhibitor, 95-100% inhibition at 2 mM in hemolymph and fat body | Apis mellifera |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| juvenile hormone III + H2O | Apis mellifera | JH esterase hydrolyzes the methyl ester to produce juvenile hormone acid | juvenile hormone III acid + methanol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Apis mellifera | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fat body | - |
Apis mellifera | - |
| hemolymph | - |
Apis mellifera | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| juvenile hormone III + H2O | - |
Apis mellifera | juvenile hormone III acid + methanol | - |
? | |
| juvenile hormone III + H2O | JH esterase hydrolyzes the methyl ester to produce juvenile hormone acid | Apis mellifera | juvenile hormone III acid + methanol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| JH esterase | - |
Apis mellifera |
| JHE | - |
Apis mellifera |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Apis mellifera |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Apis mellifera |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | JHE is the enzyme primarily performing juvenile hormone degradation in Apis mellifera, while the JH epoxide hydrolase, EC 3.3.2.9, plays a negligible role | Apis mellifera |
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Release 2023.1 (January 2023)
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