Literature summary for 3.1.1.59 extracted from

Crone, E.J.; Sutherland, T.D.; Campbell, P.M.; Coppin, C.W.; Russell, R.J.; Oakeshott, J.G.
Only one esterase of Drosophila melanogaster is likely to degrade juvenile hormone in vivo (2007), Insect Biochem. Mol. Biol., 37, 540-549.

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Inhibitors

Inhibitors	Comment	Organism	Structure
diisopropyl fluorophosphate	50% inhibition at 0.002 mM	Drosophila melanogaster
hydroprene	50% inhibition at 8 mM	Drosophila melanogaster
kinoprene	50% inhibition at 2 mM	Drosophila melanogaster
methoprene	50% inhibition at 2 mM	Drosophila melanogaster
octylthiotrifluoropropanone	50% inhibition below 1 nM	Drosophila melanogaster

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1.3	-	juvenile hormone III	10R isomer of juvenile hormone III	Drosophila melanogaster
1.5	-	juvenile hormone III	racemic juvenile hormone III	Drosophila melanogaster
2.4	-	juvenile hormone III	10S isomer of juvenile hormone III	Drosophila melanogaster
3.7	-	methyl farnesoate	-	Drosophila melanogaster
4.2	-	juvenile hormone I	-	Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Drosophila melanogaster	there is probably only one physiologically functional JHE in Drosophila melanogaster but multiple esterases with JH esterase activity	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	A1ZA98	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
juvenile hormone I + H2O	-	Drosophila melanogaster	juvenile hormone I acid + methanol	-	?
juvenile hormone III + H2O	10R-juvenile hormone III is the natural isomer	Drosophila melanogaster	juvenile hormone III acid + methanol	-	?
methyl farnesoate + H2O	-	Drosophila melanogaster	methanol + farnesoic acid	-	?
additional information	there is probably only one physiologically functional JHE in Drosophila melanogaster but multiple esterases with JH esterase activity	Drosophila melanogaster	?	-	?
additional information	no activity with juvenile hormone II	Drosophila melanogaster	?	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.8	-	juvenile hormone III	10S isomer of juvenile hormone III	Drosophila melanogaster
1	-	juvenile hormone III	racemic juvenile hormone III	Drosophila melanogaster
1.1	-	juvenile hormone III	10R isomer of juvenile hormone III	Drosophila melanogaster
1.6	-	juvenile hormone I	-	Drosophila melanogaster
3	-	methyl farnesoate	-	Drosophila melanogaster

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Release 2023.1 (January 2023)