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Literature summary for 3.1.1.5 extracted from
- Identification of an Insulin-regulated Lysophospholipase with homology to neuropathy target esterase (2008), J. Biol. Chem., 283, 5908-5917.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into the vectors pcDNA4HisMax and pEGFP-C1 | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Insulin | insulin reduces NRE mRNA levels in a dose-dependent manner in 3T3-L1 adipocytes | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Mus musculus | 5783 | - |
| lipid droplet | - |
Mus musculus | 5811 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| cytosolic fractions of COS7 cell extracts containing His-tagged NRE are loaded onto a Q-Sepharose column | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| 3T3-L1 cell | - |
Mus musculus | - |
| adipose tissue | - |
Mus musculus | - |
| brain | - |
Mus musculus | - |
| cardiac muscle | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| skeletal muscle | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | hydrolyzes sn-1 esters in lysophosphatidylcholine and lysophosphatidic acid | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lysophospholipase | - |
Mus musculus |
| NRE | - |
Mus musculus |
| NTE-related esterase | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
activity assay | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | - |
activity assay | Mus musculus |
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Release 2023.1 (January 2023)
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