Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P47713 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
phospholipase A2IValpha | - |
Mus musculus |
PLA2IValpha | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | isoform PLA2IValpha is selectively activated upon Fc receptor-mediated phagocytosis in macrophages and rapidly translocates to the site of the nascent phagosome. Pharmacological inhibition of PLA2IValpha by pyrrophenone reduces particle internalization by up to 50%. Fibroblasts from PLA2IValpha knock-out mice overexpressing FcRIIA and able to internalize IgG-opsonized beads show 50% lower phagocytosis, compared with wild-type cells. Transfection of the catalytically inactive deleted PLA2IValpha mutant PLA2IValpha(1-525) and point mutant PLA2IValpha-S228C promotes recovery of this impaired function. Transfection of the PLA2IValpha C2 domain, but not of PLA2IValpha-D43N, which cannot bind to membranes, rescues FcR-mediated phagocytosis | Mus musculus |