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Literature summary for 3.1.1.4 extracted from
- 1-Cysteine peroxiredoxin: A dual-function enzyme with peroxidase and acidic Ca2+-independent phospholipase A2 activities (2010), Biochimie, 92, 638-644.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C47S | the mutation results in the loss of peroxidase activity but acidic Ca2+-independent phospholipase A2 activity remains intact | Homo sapiens |
| S32A | the mutation abolishes acidic Ca2+-independent phospholipase A2 activity while the peroxidase activity remained unaffected | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not dependent upon Ca2+ | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25000 | - |
x * 25000 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | high levels of expression of 1-CysPrx/aiPLA2 | Homo sapiens | - |
| mesothelioma cell | high levels of expression of 1-CysPrx/aiPLA2 | Homo sapiens | - |
| squamous cell carcinoma cell | high levels of expression of 1-CysPrx/aiPLA2 | Homo sapiens | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 25000 | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 1-CysPrx | a dual-function enzyme with peroxidase and acidic Ca2+-independent phospholipase A2 activities, also known as peroxiredoxin VI, non-selenium glutathione peroxidase, LTW4, antioxidant protein 2 (AOP2), Clara cell protein 26 (CC26) and p67phox binding protein | Homo sapiens |
| 1-cysteine peroxiredoxin | a dual-function enzyme with peroxidase and acidic Ca2+-independent phospholipase A2 activities | Homo sapiens |
| acidic Ca2+-independent phospholipase A2 | - |
Homo sapiens |
| aiPLA2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the functions of 1-CysPrx/aiPLA2 include the protection of cell membrane phospholipids against oxidative damage (peroxidation) and the metabolism (hydrolysis) of phospholipids, such as those of lung surfactant | Homo sapiens |
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Release 2023.1 (January 2023)
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